U73122 supplier|U-73122|DC Chemicals

U73122 supplier|U-73122|DC Chemicals
DC Chemicals provides U73122, other names: U 73122，U-73122, cas: 112648-68-7. In stock.

Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643296；

U-73122 is an inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase).

U73122, other names: U 73122，U-73122, cas: 112648-68-7, Molecule formular: C29H40N2O3, Molecule Weight: 464.64, Chemical name: 1-[6-[[(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]amino]hexyl]pyrrole-2,5-dione

In neutrophils and human platelets, U-73122 inhibits agonist-induced phospholipase C (IC50=1.0-2.1 μM) activation. This compound affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. In SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73122 is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences. For the detailed information of U73122, the solubility of U73122 in water, the solubility of U73122 in DMSO, the solubility of U73122 in PBS buffer, the animal experiment (test) of  U73122, the cell expriment (test) of U73122, the in vivo, in vitro and clinical trial test of U73122, the EC50, IC50,and affinity,of U73122, Please contact DC Chemicals.