2014年5月3日星期六

GSK1120212 (JTP-74057, trametinib) |cas 871700-17-3 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: GSK1120212 (JTP-74057, trametinib) ,cas 871700-17-3, Cat No. DC1099, In stock

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Product name: GSK-1120212 (JTP-74057,trametinib), Synonym: GSK212, GSK 1120212 , JTP-74057, trametinib, GSK1120212, Cat No. DC1099, Cas: 871700-17-3, Chemical Name:N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide, Molecular Formula: C26H23FIN5O4, MW: 615.39

GSK-1120212 (JTP-74057,trametinib) Cas#871700-17-3.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.

Description of Trametinib: Trametinib is an orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of GSK1120212 (JTP-74057, trametinib) in water, the solubility of GSK1120212 (JTP-74057, trametinib) in DMSO, the solubility of GSK1120212 (JTP-74057, trametinib) in PBS buffer, the animal experiment of GSK1120212 (JTP-74057, trametinib),the in vivo and in vitro test of GSK1120212 (JTP-74057, trametinib),the cell experiment of GSK1120212 (JTP-74057, trametinib),the IC50 and EC50 of GSK1120212 (JTP-74057, trametinib)please contact DC Chemicals.

Ticagrelor (Brilinta, AZD6140) |cas 274693-27-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Ticagrelor (Brilinta, AZD6140) ,cas 274693-27-5, Cat No. DC1101, In stock

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Product name: Ticagrelor (Brilinta,AZD6140), Synonym: AZD-6140, Ticagrelor , Brilinta, AZD 6140, Cat No. DC1101, Cas: 274693-27-5, Chemical Name:1,2-Cyclopentanediol, 3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-, Molecular Formula: C23H28F2N6O4S, MW: 522.57

Ticagrelor (Brilinta,AZD6140) Cas#274693-27-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.

For the detailed information about the solubility of Ticagrelor (Brilinta, AZD6140) in water, the solubility of Ticagrelor (Brilinta, AZD6140) in DMSO, the solubility of Ticagrelor (Brilinta, AZD6140) in PBS buffer, the animal experiment of Ticagrelor (Brilinta, AZD6140),the in vivo and in vitro test of Ticagrelor (Brilinta, AZD6140),the cell experiment of Ticagrelor (Brilinta, AZD6140),the IC50 and EC50 of Ticagrelor (Brilinta, AZD6140)please contact DC Chemicals.

Tariquidar |cas 206873-63-4 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Tariquidar ,cas 206873-63-4, Cat No. DC1102, In stock

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Product name: Tariquidar (XR9576), Synonym: N/A, Cat No. DC1102, Cas: 206873-63-4, Chemical Name:3-Quinolinecarboxamide, N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-, Molecular Formula: C38H38N4O6, MW: 646.73

Tariquidar Cas#206873-63-4.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Tariquidar (XR9576) is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM.

Description of Tariquidar: Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of Tariquidar in water, the solubility of Tariquidar in DMSO, the solubility of Tariquidar in PBS buffer, the animal experiment of Tariquidar,the in vivo and in vitro test of Tariquidar,the cell experiment of Tariquidar,the IC50 and EC50 of Tariquidarplease contact DC Chemicals.

Hesperadin |cas 422513-13-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Hesperadin ,cas 422513-13-1, Cat No. DC1103, In stock

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Product name: Hesperadin, Synonym: N/A, Cat No. DC1103, Cas: 422513-13-1, Chemical Name:(Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide, Molecular Formula: C29H32N4O3S, MW: 516.65

Hesperadin Cas#422513-13-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Hesperadin inhibits Aurora B and T. brucei Aurora kinase-1 (TbAUK1) with IC50 of 250 nM and 40 nM, respectively.

Descrpition of Hesperadin: Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked nuclear division and cytokinesis but not other aspects of the cell cycle. Consequently, growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effects of RNAi-dependent knockdown of TbAUK1 in cultured bloodstream forms cells. Molecular models predicted high-affinity binding of Hesperadin to both conserved and novel sites in TbAUK1. Collectively, these data demonstrate that cell cycle progression is essential for infections with T. brucei and that parasite Aurora kinases can be targeted with small-molecule inhibitors. [See: Mol Microbiol. 2009 Apr;72(2):442-58. Epub 2009 Mar 6. or http://www.ncbi.nlm.nih.gov/pubmed/19320832] .
For the detailed information about the solubility of Hesperadin in water, the solubility of Hesperadin in DMSO, the solubility of Hesperadin in PBS buffer, the animal experiment of Hesperadin,the in vivo and in vitro test of Hesperadin,the cell experiment of Hesperadin,the IC50 and EC50 of Hesperadinplease contact DC Chemicals.

Linagliptin (BI-1356) |cas 668270-12-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Linagliptin (BI-1356) ,cas 668270-12-0, Cat No. DC1105, In stock

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Product name: Linagliptin (BI-1356), Synonym: BI1356, BI 1356, Cat No. DC1105, Cas: 668270-12-0, Chemical Name:(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione, Molecular Formula: C25H28N8O2, MW: 472.54

Linagliptin (BI-1356) Cas#668270-12-0.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.

Description of Linagliptin: Linagliptin (BI-1356, trade names Tradjenta and Trajenta) is a DPP-4 inhibitor developed by Boehringer Ingelheim for treatment of type II diabetes. Linagliptin (once-daily) was approved by the US FDA on 2 May 2011 for treatment of type II diabetes.[1] It is being marketed by Boehringer Ingelheim and Lilly.
For the detailed information about the solubility of Linagliptin (BI-1356) in water, the solubility of Linagliptin (BI-1356) in DMSO, the solubility of Linagliptin (BI-1356) in PBS buffer, the animal experiment of Linagliptin (BI-1356),the in vivo and in vitro test of Linagliptin (BI-1356),the cell experiment of Linagliptin (BI-1356),the IC50 and EC50 of Linagliptin (BI-1356)please contact DC Chemicals.

PCI-32765 (Ibrutinib) |cas 936563-96-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PCI-32765 (Ibrutinib) ,cas 936563-96-1, Cat No. DC1106, In stock

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Product name: PCI-32765 (Ibrutinib), Synonym: PCI32765, Cat No. DC1106, Cas: 936563-96-1, Chemical Name:(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, Molecular Formula: C25H24N6O2, MW: 440.5

PCI-32765 (Ibrutinib) Cas#936563-96-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM.

Description of Ibrutinib (PCI-32765): Ibrutinib is a BTK inhibitor, is also an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. BTK inhibitor PCI-32765 binds to and inhibits BTK activity, preventing B-cell activation and B-cell-mediated signaling and inhibiting the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor (BCR) signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of PCI-32765 (Ibrutinib) in water, the solubility of PCI-32765 (Ibrutinib) in DMSO, the solubility of PCI-32765 (Ibrutinib) in PBS buffer, the animal experiment of PCI-32765 (Ibrutinib),the in vivo and in vitro test of PCI-32765 (Ibrutinib),the cell experiment of PCI-32765 (Ibrutinib),the IC50 and EC50 of PCI-32765 (Ibrutinib)please contact DC Chemicals.

PF-543 |cas 1415562-82-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PF-543 ,cas 1415562-82-1, Cat No. DC1107, In stock

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Product name: PF-543, Synonym: PF543, PF 543, Cat No. DC1107, Cas: 1415562-82-1, Chemical Name:2-Pyrrolidinemethanol, 1-[[4-[[3-methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-, (2R)-, Molecular Formula: C27H31NO4S, MW: 465.6

PF-543 Cas#1415562-82-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PF-543 is a novel Sphingosine kinase 1 (SphK1, SK1) inhibitor with Ki of 3.6 nM.

Description of PF-543: PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling. (source: Biochem J. 2012 May 15;444(1):79-88. doi: 10.1042/BJ20111929.)
For the detailed information about the solubility of PF-543 in water, the solubility of PF-543 in DMSO, the solubility of PF-543 in PBS buffer, the animal experiment of PF-543,the in vivo and in vitro test of PF-543,the cell experiment of PF-543,the IC50 and EC50 of PF-543please contact DC Chemicals.

Laninamivir (CS-8958) |cas 203120-17-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Laninamivir (CS-8958) ,cas 203120-17-6, Cat No. DC1108, In stock

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Product name: Laninamivir (CS-8958), Synonym: CS8958, Cat No. DC1108, Cas: 203120-17-6, Chemical Name:N/A, Molecular Formula: C13H22N4O7, MW: 346.34

Laninamivir (CS-8958) Cas#203120-17-6.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Laninamivir (CS-8958) is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.

Laninamivir (CS-8958) is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.[1] It is currently in Phase III clinical trials. [2]
Laninamivir was approved for influenza treatment in Japan in 2010 and is currently marketed under the name "Inavir" by Daiichi Sankyo. Biota Pharmaceuticals [3] and Daiichi Sankyo co-own Laninamivir. On 1st April 2011, BARDA awarded up to an estimated U$231m to Biota Pharmaceuticals (Formerly Biota Holdings Ltd) wholly owned subsidiary, Biota Scientific Management Pty Ltd, for the advanced development of Laninamivir in the US. [4]For the detailed information about the solubility of Laninamivir (CS-8958) in water, the solubility of Laninamivir (CS-8958) in DMSO, the solubility of Laninamivir (CS-8958) in PBS buffer, the animal experiment of Laninamivir (CS-8958),the in vivo and in vitro test of Laninamivir (CS-8958),the cell experiment of Laninamivir (CS-8958),the IC50 and EC50 of Laninamivir (CS-8958)please contact DC Chemicals.

PCI-34051 |cas 950762-95-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PCI-34051 ,cas 950762-95-5, Cat No. DC1109, In stock

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Product name: PCI-34051, Synonym: PCI34051, PCI 34051, Cat No. DC1109, Cas: 950762-95-5, Chemical Name:1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide, Molecular Formula: C17H16N2O3, MW: 296.32

PCI-34051 Cas#950762-95-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM.

For the detailed information about the solubility of PCI-34051 in water, the solubility of PCI-34051 in DMSO, the solubility of PCI-34051 in PBS buffer, the animal experiment of PCI-34051,the in vivo and in vitro test of PCI-34051,the cell experiment of PCI-34051,the IC50 and EC50 of PCI-34051please contact DC Chemicals.

Phenprocoumon (Marcumar) |cas 435-97-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Phenprocoumon (Marcumar)  ,cas 435-97-2, Cat No. DC1110, In stock

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Product name: Phenprocoumon (Marcumar), Synonym: Marcuma, Cat No. DC1110, Cas: 435-97-2, Chemical Name:N/A, Molecular Formula: C18H16O3, MW: 280.32

Phenprocoumon (Marcumar) Cas#435-97-2.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Phenprocoumon is closely related to warfarin and is an anticoagulant drug used to thin the blood, or stop it from clotting.

Phenprocoumon is closely related to warfarin and is an anticoagulant drug used to thin the blood, or stop it from clotting. It is derived from coumarin and works by blocking the action of vitamin K, which is an essential ingredient in the body's clotting process. A number of different drugs containing phenprocoumon are available in some countries of the world. They are known by different trade names, according to manufacturer.For the detailed information about the solubility of Phenprocoumon (Marcumar)  in water, the solubility of Phenprocoumon (Marcumar)  in DMSO, the solubility of Phenprocoumon (Marcumar)  in PBS buffer, the animal experiment of Phenprocoumon (Marcumar) ,the in vivo and in vitro test of Phenprocoumon (Marcumar) ,the cell experiment of Phenprocoumon (Marcumar) ,the IC50 and EC50 of Phenprocoumon (Marcumar) please contact DC Chemicals.

UK-5099 (UK5099 ) |cas 56396-35-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: UK-5099 (UK5099 ) ,cas 56396-35-1, Cat No. DC1111, In stock

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Product name: UK-5099, Synonym: UK5099, UK 5099, Cat No. DC1111, Cas: 56396-35-1, Chemical Name:N/A, Molecular Formula: C18H12N2O2, MW: 288.31

UK-5099  Cas#56396-35-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! UK5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).

For the detailed information about the solubility of UK-5099 (UK5099 ) in water, the solubility of UK-5099 (UK5099 ) in DMSO, the solubility of UK-5099 (UK5099 ) in PBS buffer, the animal experiment of UK-5099 (UK5099 ),the in vivo and in vitro test of UK-5099 (UK5099 ),the cell experiment of UK-5099 (UK5099 ),the IC50 and EC50 of UK-5099 (UK5099 )please contact DC Chemicals.

Everolimus |cas 159351-69-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Everolimus ,cas 159351-69-6, Cat No. DC1501, In stock

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Product name: Everolimus, Synonym: Certican, Zortress, Afinitor, Cat No. DC1501, Cas: 159351-69-6, Chemical Name:23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv, Molecular Formula: C53H83NO14, MW: 958.22

Everolimus Cas#159351-69-6.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.

Description of everolimus: Everolimus is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of Everolimus in water, the solubility of Everolimus in DMSO, the solubility of Everolimus in PBS buffer, the animal experiment of Everolimus,the in vivo and in vitro test of Everolimus,the cell experiment of Everolimus,the IC50 and EC50 of Everolimusplease contact DC Chemicals.

PTC124 (Ataluren) |cas 775304-57-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PTC124 (Ataluren) ,cas 775304-57-9, Cat No. DC2005, In stock

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Product name: PTC124 (Ataluren), Synonym: Ataluren, PTC-124, Cat No. DC2005, Cas: 775304-57-9, Chemical Name:3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid, Molecular Formula: C15H9FN2O3, MW: 284.24

PTC124 (Ataluren) Cas#775304-57-9.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PTC124 (Ataluren) is a potent nonsense mutation inhibitor with EC50 of ~0.1 μM.

Description of Ataluren:  Ataluren (PTC124?) is an investigational new drug designed to enable the formation of a functioning protein in patients with genetic disorders due to a nonsense mutation. A nonsense mutation is an alteration in the genetic code that prematurely halts the synthesis of an essential protein. Ataluren is currently being investigated for use in patients with nonsense mutation Duchenne/Becker muscular dystrophy (nmDBMD) and cystic fibrosis (nmCF) (source: http://www.ptcbio.com/ataluren).
For the detailed information about the solubility of PTC124 (Ataluren) in water, the solubility of PTC124 (Ataluren) in DMSO, the solubility of PTC124 (Ataluren) in PBS buffer, the animal experiment of PTC124 (Ataluren),the in vivo and in vitro test of PTC124 (Ataluren),the cell experiment of PTC124 (Ataluren),the IC50 and EC50 of PTC124 (Ataluren)please contact DC Chemicals.

TAK-700 (Orteronel)|cas 566939-85-3 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: TAK-700 (Orteronel),cas 566939-85-3, Cat No. DC2009, In stock

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Product name: TAK-700 (Orteronel), Synonym: TAK700, Orteronel, TAK 700, Cat No. DC2009, Cas: 566939-85-3, Chemical Name:(S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-e]imidazol-7-yl)-N-methyl-2-naphthamide, Molecular Formula: C18H17N3O2, MW: 307.35

TAK-700 (Orteronel)
 Cas#566939-85-3.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively.

Description of orteronel: Orterone (TAK-700) is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of TAK-700 (Orteronel)
 in water, the solubility of TAK-700 (Orteronel)
 in DMSO, the solubility of TAK-700 (Orteronel)
 in PBS buffer, the animal experiment of TAK-700 (Orteronel)
,the in vivo and in vitro test of TAK-700 (Orteronel)
,the cell experiment of TAK-700 (Orteronel)
,the IC50 and EC50 of TAK-700 (Orteronel)
please contact DC Chemicals.

Bedaquiline (TMC207) |cas 843663-66-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Bedaquiline (TMC207) ,cas 843663-66-1, Cat No. DC2012, In stock

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Product name: Bedaquiline (TMC207), Synonym: Bedaquiline, TMC-207, Cat No. DC2012, Cas: 843663-66-1, Chemical Name:N/A, Molecular Formula: C31H29BrN2O, MW: 525.487

Bedaquiline (TMC207) Cas#843663-66-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.For the detailed information about the solubility of Bedaquiline (TMC207) in water, the solubility of Bedaquiline (TMC207) in DMSO, the solubility of Bedaquiline (TMC207) in PBS buffer, the animal experiment of Bedaquiline (TMC207),the in vivo and in vitro test of Bedaquiline (TMC207),the cell experiment of Bedaquiline (TMC207),the IC50 and EC50 of Bedaquiline (TMC207)please contact DC Chemicals.

Bafetinib (INNO-406) |cas 887650-05-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Bafetinib (INNO-406)  ,cas 887650-05-7, Cat No. DC2013, In stock

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Product name: Bafetinib (INNO-406), Synonym: NS-187, Bafetinib, INNO406, Cat No. DC2013, Cas: 887650-05-7, Chemical Name:(S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide, Molecular Formula: C30H31F3N8O, MW: 576.62

Bafetinib (INNO-406) Cas#887650-05-7.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM and 19 nM, respectively.

Description of Bafetinib: Bafetinib is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). This agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types. The inhibitory effect of bafetinib on these specific tyrosine kinases may decrease cellular proliferation and induce apoptosis in tumor cells that overexpress these kinases. CML patients may be refractory to imatinib, which sometimes results from point mutations occurring in the kinase domain of the Bcr/Abl fusion product. Due to its dual inhibitory activity, the use of bafetinib has been shown to overcome this particular drug resistance. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
For the detailed information about the solubility of Bafetinib (INNO-406)  in water, the solubility of Bafetinib (INNO-406)  in DMSO, the solubility of Bafetinib (INNO-406)  in PBS buffer, the animal experiment of Bafetinib (INNO-406) ,the in vivo and in vitro test of Bafetinib (INNO-406) ,the cell experiment of Bafetinib (INNO-406) ,the IC50 and EC50 of Bafetinib (INNO-406) please contact DC Chemicals.

Flavopiridol |cas 146426-40-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Flavopiridol ,cas 146426-40-6, Cat No. DC2014, In stock

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Product name: Flavopiridol, Synonym: HMR-1275, L86-8275, Cat No. DC2014, Cas: 146426-40-6, Chemical Name:2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride, Molecular Formula: C21H20ClNO5.HCl, MW: 438.3

Flavopiridol Cas#146426-40-6.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM.

Alvocidib is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
For the detailed information about the solubility of Flavopiridol in water, the solubility of Flavopiridol in DMSO, the solubility of Flavopiridol in PBS buffer, the animal experiment of Flavopiridol,the in vivo and in vitro test of Flavopiridol,the cell experiment of Flavopiridol,the IC50 and EC50 of Flavopiridolplease contact DC Chemicals.

AT-101 (AT101) |cas 90141-22-3 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: AT-101 (AT101) ,cas 90141-22-3, Cat No. DC2015, In stock

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Product name: AT-101 (AT101), Synonym: AT 101, AT101, Cat No. DC2015, Cas: 90141-22-3, Chemical Name:[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)-, Molecular Formula: C30H30O8, MW: 518.55

AT-101 (AT101) Cas#90141-22-3.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.

For the detailed information about the solubility of AT-101 (AT101) in water, the solubility of AT-101 (AT101) in DMSO, the solubility of AT-101 (AT101) in PBS buffer, the animal experiment of AT-101 (AT101),the in vivo and in vitro test of AT-101 (AT101),the cell experiment of AT-101 (AT101),the IC50 and EC50 of AT-101 (AT101)please contact DC Chemicals.

MLN8237 (Alisertib) |cas 1028486-01-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: MLN8237 (Alisertib) ,cas 1028486-01-2, Cat No. DC2016, In stock

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Product name: MLN8237 (Alisertib), Synonym: MLN-8237, MLN 8237, Cat No. DC2016, Cas: 1028486-01-2, Chemical Name:Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-, Molecular Formula: C27H20ClFN4O4, MW: 518.92

MLN8237 (Alisertib) Cas#1028486-01-2.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM.

Description of Alisertib (MLN8237): MLN8237 is a second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Aurora kinase inhibitor MLN8237 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
For the detailed information about the solubility of MLN8237 (Alisertib) in water, the solubility of MLN8237 (Alisertib) in DMSO, the solubility of MLN8237 (Alisertib) in PBS buffer, the animal experiment of MLN8237 (Alisertib),the in vivo and in vitro test of MLN8237 (Alisertib),the cell experiment of MLN8237 (Alisertib),the IC50 and EC50 of MLN8237 (Alisertib)please contact DC Chemicals.

LY335979 (Zosuquidar 3HCl) |cas 167465-36-3 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: LY335979 (Zosuquidar 3HCl) ,cas 167465-36-3, Cat No. DC2018, In stock

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Product name: LY335979 (Zosuquidar 3HCl), Synonym: RS-33295-198, Zosuquidar, LY-335979, Cat No. DC2018, Cas: 167465-36-3, Chemical Name:1-Piperazineethanol, 4-[(1aα,6α,10bα)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-,trihydrochloride, Molecular Formula: C32H31F2N3O2.3HCl, MW: 636.99

LY335979 (Zosuquidar 3HCl) Cas#167465-36-3.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! LY335979 (Zosuquidar) is a potent modulator of P-glycoprotein-mediated multidrug resistance with Ki of 60 nM.

Description of Zosuquidar: Zosuquidar is a potent P-glycoprotein inhibitor, which binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of LY335979 (Zosuquidar 3HCl) in water, the solubility of LY335979 (Zosuquidar 3HCl) in DMSO, the solubility of LY335979 (Zosuquidar 3HCl) in PBS buffer, the animal experiment of LY335979 (Zosuquidar 3HCl),the in vivo and in vitro test of LY335979 (Zosuquidar 3HCl),the cell experiment of LY335979 (Zosuquidar 3HCl),the IC50 and EC50 of LY335979 (Zosuquidar 3HCl)please contact DC Chemicals.

Brivanib (BMS-540215) |cas 649735-46-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Brivanib (BMS-540215) ,cas 649735-46-6, Cat No. DC2019, In stock

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Product name: Brivanib (bms-540215), Synonym: bms540215, bms 540215, Cat No. DC2019, Cas: 649735-46-6, Chemical Name:(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol, Molecular Formula: C19H19FN4O3, MW: 370.38

Brivanib (bms-540215) Cas#649735-46-6.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively.

Brivanib is the hydrolyzed form of Brivanib alaninate, which is a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of Brivanib (bms-540215) in water, the solubility of Brivanib (bms-540215) in DMSO, the solubility of Brivanib (bms-540215) in PBS buffer, the animal experiment of Brivanib (bms-540215),the in vivo and in vitro test of Brivanib (bms-540215),the cell experiment of Brivanib (bms-540215),the IC50 and EC50 of Brivanib (bms-540215)please contact DC Chemicals.

Perifosine (KRX-0401) |cas 157716-52-4 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Perifosine (KRX-0401) ,cas 157716-52-4, Cat No. DC2021, In stock

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Product name: Perifosine (KRX-0401), Synonym: KRX0401, KRX 0401, Cat No. DC2021, Cas: 157716-52-4, Chemical Name:Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt, Molecular Formula: C25H52NO4P, MW: 461.66

Perifosine (KRX-0401) Cas#157716-52-4.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM.

Description of Perifosine: Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of Perifosine (KRX-0401) in water, the solubility of Perifosine (KRX-0401) in DMSO, the solubility of Perifosine (KRX-0401) in PBS buffer, the animal experiment of Perifosine (KRX-0401),the in vivo and in vitro test of Perifosine (KRX-0401),the cell experiment of Perifosine (KRX-0401),the IC50 and EC50 of Perifosine (KRX-0401)please contact DC Chemicals.

LY2183240 |cas 874902-19-9|DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: LY2183240 ,cas 874902-19-9, Cat No. DC2045, In stock

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Product name: LY2183240, Synonym: LY-2183240, LY 2183240, Cat No. DC2045, Cas: 874902-19-9, Chemical Name:N/A, Molecular Formula: C17H17N5O, MW: 307

LY2183240 Cas#874902-19-9
.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! LY2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM).

LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, LY2183240 increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.For the detailed information about the solubility of LY2183240 in water, the solubility of LY2183240 in DMSO, the solubility of LY2183240 in PBS buffer, the animal experiment of LY2183240,the in vivo and in vitro test of LY2183240,the cell experiment of LY2183240,the IC50 and EC50 of LY2183240please contact DC Chemicals.

Cobicistat (GS-9350) |cas 1004316-88-4 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Cobicistat (GS-9350)  ,cas 1004316-88-4, Cat No. DC2046, In stock

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Product name: Cobicistat (GS-9350), Synonym: GS 9350, GS9350, Cat No. DC2046, Cas: 1004316-88-4, Chemical Name:2,7,10,12-Tetraazatridecanoic acid, 12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3R,6R,9S)-, Molecular Formula: C40H53N7O5S2, MW: 776.02

Cobicistat (GS-9350) Cas#1004316-88-4.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.

Description of Cobicistat: Cobicistat is an approved drug for use in the treatment of infection with the human immunodeficiency virus (HIV). Like ritonavir (Norvir), cobicistat is of interest not for its anti-HIV properties, but rather its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor currently under investigation itself. By combining cobicistat with elvitegravir, higher concentrations of elvitgravir are achieved in the body with lower dosing, theoretically enhancing elvitgravir's viral suppression while diminishing its adverse side-effects. In contrast with ritonavir, the only currently approved booster, cobicistat has no anti-HIV activity of its own. Cobicistat is a component of the four-drug, fixed-dose combination HIV treatment elvitegravir/cobicistat/emtricitabine/tenofovir (known as the "Quad Pill"). The Quad Pill was approved by the FDA in August 2012 for use in the United States and is owned by Gilead Sciences. (source: http://en.wikipedia.org/wiki/Cobicistat).
For the detailed information about the solubility of Cobicistat (GS-9350)  in water, the solubility of Cobicistat (GS-9350)  in DMSO, the solubility of Cobicistat (GS-9350)  in PBS buffer, the animal experiment of Cobicistat (GS-9350) ,the in vivo and in vitro test of Cobicistat (GS-9350) ,the cell experiment of Cobicistat (GS-9350) ,the IC50 and EC50 of Cobicistat (GS-9350) please contact DC Chemicals.

Crizotinib (PF-2341066) |cas 877399-52-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Crizotinib (PF-2341066) ,cas 877399-52-5, Cat No. DC2047, In stock

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Product name: Crizotinib (PF-2341066), Synonym: PF 2341066, PF2341066, Cat No. DC2047, Cas: 877399-52-5, Chemical Name:3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine, Molecular Formula: C21H22Cl2FN5O, MW: 450.34

Crizotinib (PF-2341066) Cas#877399-52-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley.

Description of Crizotinib: Crizotinib is an orally bioavailable agent belonging to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. Crizotinib was approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and childre. Crizotinib inhibits the membrane receptor MET and activation of the MET signaling pathway, which may block tumor cell growth, migration and invasion, and tumor angiogenesis in susceptible tumor cell populations. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) .
For the detailed information about the solubility of Crizotinib (PF-2341066) in water, the solubility of Crizotinib (PF-2341066) in DMSO, the solubility of Crizotinib (PF-2341066) in PBS buffer, the animal experiment of Crizotinib (PF-2341066),the in vivo and in vitro test of Crizotinib (PF-2341066),the cell experiment of Crizotinib (PF-2341066),the IC50 and EC50 of Crizotinib (PF-2341066)please contact DC Chemicals.