Hesperadin |cas 422513-13-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Hesperadin ,cas 422513-13-1, Cat No. DC1103, In stock

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Product name: Hesperadin, Synonym:　N/A, Cat No. DC1103, Cas: 422513-13-1, Chemical Name:(Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide, Molecular Formula: C29H32N4O3S, MW: 516.65

Hesperadin Cas#422513-13-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! Hesperadin inhibits Aurora B and T. brucei Aurora kinase-1 (TbAUK1) with IC50 of 250 nM and 40 nM, respectively.

Descrpition of Hesperadin: Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked nuclear division and cytokinesis but not other aspects of the cell cycle. Consequently, growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effects of RNAi-dependent knockdown of TbAUK1 in cultured bloodstream forms cells. Molecular models predicted high-affinity binding of Hesperadin to both conserved and novel sites in TbAUK1. Collectively, these data demonstrate that cell cycle progression is essential for infections with T. brucei and that parasite Aurora kinases can be targeted with small-molecule inhibitors. [See: Mol Microbiol. 2009 Apr;72(2):442-58. Epub 2009 Mar 6. or http://www.ncbi.nlm.nih.gov/pubmed/19320832] .

For the detailed information about the solubility of Hesperadin in water, the solubility of Hesperadin in DMSO, the solubility of Hesperadin in PBS buffer, the animal experiment of Hesperadin,the in vivo and in vitro test of Hesperadin,the cell experiment of Hesperadin,the IC50 and EC50 of Hesperadinplease contact DC Chemicals.