DC Chemicals: 八月 2014

2014年8月30日星期六

MLN2238 supplier|cas 1072833-77-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: MLN2238 supplier,cas 1072833-77-2, Cat No. DC5086, In stock

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Product name: MLN2238, Synonym:　MLN-2238; MLN 2238; MLN2238., Cat No. DC5086, Cas: 1072833-77-2, Chemical Name:(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid, Molecular Formula: C14H19BCl2N2O4, MW: 361.03

MLN2238,cas 1072833-77-2, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM.

MLN-2238 is the biologically active form of MLN9708. MLN2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both MLN2238 and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only MLN2238 alleviated osteolytic bone disease in the DP54-Luc model. The antitumor activity of MLN2238 in a variety of mouse models of B-cell lymphoma and PCM, supporting its clinical development.

1Mps1-IN-1 supplier|cas 1125593-20-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: 1Mps1-IN-1 supplier,cas 1125593-20-5, Cat No. DC5087, In stock

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Product name: 1Mps1-IN-1, Synonym:　N/A, Cat No. DC5087, Cas: 1125593-20-5, Chemical Name:N/A, Molecular Formula: C28H33N5O4S, MW: 535.66

1Mps1-IN-1,cas 1125593-20-5, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC.

WYE125132 supplier|cas 1144068-46-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: WYE125132 supplier,cas 1144068-46-1, Cat No. DC5088, In stock

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Product name: WYE125132, Synonym:　WYE-125132,WYE 125132, Cat No. DC5088, Cas: 1144068-46-1, Chemical Name:N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea, Molecular Formula: C27H33N7O4, MW: 519.6

WYE125132,cas 1144068-46-1, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. WYE125132 is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor

WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. WYE-125132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. WYE-125132 causes pre-tRNA Leu synthesis reduction by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively as a result of the inhibition of mTORC1. WYE-125132 induces Maf1 dephosphorylation and its accumulation in the nucleus.

Ixazomib (MLN-9708) supplier|cas 1201902-80-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Ixazomib (MLN-9708) supplier,cas 1201902-80-8, Cat No. DC5089, In stock

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Product name: Ixazomib (MLN-9708), Synonym:　Ixazomib; MLN9708, Cat No. DC5089, Cas: 1201902-80-8, Chemical Name:4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid, Molecular Formula: C20H23BCl2N2O9, MW: 517.12

Ixazomib (MLN-9708),cas 1201902-80-8, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. MLN9708 is a proteasome inhibitor, which inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome.

ixazomib is an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated.

WZ4002 supplier|cas 1213269-23-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: WZ4002 supplier,cas 1213269-23-8, Cat No. DC5090, In stock

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Product name: WZ4002, Synonym:　WZ4002,WZ 4002,WZ-4002, Cat No. DC5090, Cas: 1213269-23-8, Chemical Name:N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide, Molecular Formula: C25H27ClN6O3, MW: 494.97

WZ4002,cas 1213269-23-8, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I).

WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors. This agent is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro.

NSC-664704 supplier|cas 142273-20-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: NSC-664704 supplier,cas 142273-20-9, Cat No. DC5093, In stock

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Product name: NSC-664704, Synonym:　NSC664704,NSC 664704, Cat No. DC5093, Cas: 142273-20-9, Chemical Name:KENPAULLONE;8-BROMO-7,12-DIHYDRO-INDOLO[3,2-D][1]-BENZAZEPIN-6(5H)-ONE;KENPAULLONE;NSC-664704;9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one,, Molecular Formula: C16H11BrN2O, MW: 327.2

NSC-664704,cas 142273-20-9, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. The development of selective, cell-permeable protein kinase inhibitors for the treatment of cancer, inflammation, and other diseases, is a major focus of drug development efforts. Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK-3β).It inhibits GSK-3β with an IC50 value of 0.023 ?M (0.23 ?M) and CDK1/cyclin B, CDK2/cyclin A, CDK5/p25, and lymphocyte kinase with IC50 values of 0.4, 0.68, 0.85, and 0.47 ?M, respectively.

PD169316 supplier|cas 152121-53-4 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PD169316 supplier,cas 152121-53-4, Cat No. DC5095, In stock

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Product name: PD169316, Synonym:　PD 169316,PD-169316, Cat No. DC5095, Cas: 152121-53-4, Chemical Name:4-[4-(4-Fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine, Molecular Formula: C20H13FN4O2, MW: 360.3

PD169316,cas 152121-53-4, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. PD169316 is a potent and selective p38 MAP kinase inhibitor

PD 169316 is a potent, cell-permeable, and selective p38α (p38 MAP kinase) inhibitor (IC50 = 89 nM). Inhibition of p38α (p38 MAP kinase) by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.

PD 98059 supplier|cas 167869-21-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PD 98059 supplier,cas 167869-21-8, Cat No. DC5100, In stock

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Product name: PD 98059, Synonym:　PD-98059,PD98059, Cat No. DC5100, Cas: 167869-21-8, Chemical Name:;2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE;2-(2-AMINO-3-METHOXY-PHENYL)CHROMEN-4-ONE;2'-AMINO-3'-METHOXYFLAVONE, Molecular Formula: C16H13NO3, MW: 267.28

PD 98059,cas 167869-21-8, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. PD 98059 is a selective inhibitor of MEK and blocker of MAPK

PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1 (MAPKK1 or MAPKs ) that binds to the inactive form of MEK-1 blocking MEK-1 activation leading to inhibition of phosphorylation and the activation of MAP kinase. In PC12 pheochromocytoma cells at an IC50= 2 μM, it produced complete blockage of any increase in MAPK activity produced by nerve growth factor. It has been shown to enhance self-renewal of embryonic stem cells and has been used to unravel the role of the MAPK cascade in biological systems. The compound has been reported to induce GSTA2 (glutathione S-transferase A2) production in H4IIE cells. PD 98059 has also been shown to enhance insulin-mediated increase in glutathione levels as well as, independent of MEK1 inhibition, elevate primary cultured rat hepatocyte glutathione levels.

Favipiravir (T-705) supplier|cas 259793-96-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Favipiravir (T-705) supplier,cas 259793-96-9, Cat No. DC5105, In stock

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Product name: Favipiravir (T-705), Synonym:　T 705; Favipiravir;T-705;T705, Cat No. DC5105, Cas: 259793-96-9, Chemical Name:fluoro-3,4-dihydro-3-oxo- (9CI);6-Fluoro-3-hydroxypyrazine-2-carboxamide;Favipiravir;Unii-ew5gl2X7E0;6-fluoro-3,4-dihydro-3-oxo-Pyrazinecarboxamide, Molecular Formula: C5H4FN3O2, MW: 157.1

Favipiravir (T-705),cas 259793-96-9, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. T 705(Favipiravir) is a RNA-directed RNA polymerase NS5B inhibitor.T 705(Favipiravir) is useful for Antiviral agents.

AG14361 supplier|cas 328543-09-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: AG14361 supplier,cas 328543-09-5, Cat No. DC5106, In stock

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Product name: AG14361, Synonym:　AG14361; AG-14361; AG 14361., Cat No. DC5106, Cas: 328543-09-5, Chemical Name:;Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-, Molecular Formula: C19H20N4O, MW: 320.39

AG14361,cas 328543-09-5, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides.

AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells.

SB-71599 (Ispinesib29) supplier|cas 336113-53-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: SB-71599 (Ispinesib29) supplier,cas 336113-53-2, Cat No. DC5107, In stock

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Product name: SB-71599 (Ispinesib29), Synonym:　Ispinesib29;SB-71599, Cat No. DC5107, Cas: 336113-53-2, Chemical Name:N/A, Molecular Formula: C30H33ClN4O2, MW: 517.06

SB-71599 (Ispinesib29),cas 336113-53-2, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively.

Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. Ispinesib (SB 715992) has cytotoxic activity at less than 10 nM in a spectrum of tumor cell lines. Ispinesib (SB 715992) is negative in a mouse model of peripheral neuropathy in which paclitaxel is positive. Ispinesib (SB 715992) was shown to have activity against advanced human colon tumor xenografts including: Colo205 (complete regressi), Colo201 (complete regressi), and HT-29 (tumor growth delay). Ispinesib (SB 715992) (10 mg/kg) induced unexplained toxicity in mice bearing osteosarcoma xenografts. Ispinesib (SB 715992) enhanced the antitumor activity of trastuzumab, lapatinib, doxorubicin, and capecitabine and exhibited activity comparable with paclitaxel and ixabepilone.

BAY 59-7939 (Rivaroxaban) supplier|cas 366789-02-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: BAY 59-7939 (Rivaroxaban) supplier,cas 366789-02-8, Cat No. DC5108, In stock

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Product name: BAY 59-7939 (Rivaroxaban), Synonym:　N/A, Cat No. DC5108, Cas: 366789-02-8, Chemical Name:5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide;Xarelto, Molecular Formula: C19H18ClN3O5S, MW: 435.88

BAY 59-7939 (Rivaroxaban),cas 366789-02-8, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders.

Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. Rivaroxaban (Xarelto; BAY 59-7939) inhibits clot-associated,free FXa activity,and prothrombinase activity, in addition, it reduces thrombin generation. Rivaroxaban (Xarelto; BAY 59-7939) is useful for antithrombotic agent

NSC157100 supplier|cas 39204-49-4 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: NSC157100 supplier,cas 39204-49-4, Cat No. DC5110, In stock

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Product name: NSC157100, Synonym:　N/A, Cat No. DC5110, Cas: 39204-49-4, Chemical Name:(PYRAZIN-2-YL)METHANAMINEHYDROCHLORIDE;pyrazin-2-ylmethanamine;2-Aminomethylpyrazine hydrochloride;, Molecular Formula: C5H8ClN3, MW: 145.59

NSC157100,cas 39204-49-4, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC.

PHA-680632 supplier|cas 398493-79-3 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PHA-680632 supplier,cas 398493-79-3, Cat No. DC5111, In stock

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Product name: PHA-680632, Synonym:　PHA-680632; PHA 680632; PHA680632., Cat No. DC5111, Cas: 398493-79-3, Chemical Name:N/A, Molecular Formula: C28H35N7O2, MW: 501.62

PHA-680632,cas 398493-79-3, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.

PHA-680632 is a is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM. PHA-680632 is also the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic.

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