Monomethyl auristatin E (MMAE, vedotin)|cas 474645-27-7| DC Chem|Supplier|Price|Buy

Monomethyl auristatin E (MMAE, vedotin)|cas 474645-27-7| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: Monomethyl auristatin E (MMAE, vedotin)|cas 474645-27-7,Purity: >98% ,Cat No. DC7021, In stock.

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Monomethyl auristatin E (MMAE, vedotin)|cas 474645-27-7 ,Synonym: MMAE, vedotin ,Chemical name:  ,Molecular Formula: C39H67N5O7 ,MW:717.98

Monomethyl auristatin E (MMAE, vedotin), cas 474645-27-7,Purity: >98%, Best Price and quality from DC Chemicals. Monomethyl auristatin E (MMAE; Vedotin) is a hot topic in Antibody-drug conjugates (ADCs) studies. It is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.

Monomethyl auristatin E (MMAE, vedotin) is a very potent anti-mitotic agent that inhibits cell division by

blocking the polymerisation of tubulin. Because of its super toxicity, it cannot be used as a drug itself. In

recent cancer therapy developments, it is linked to a monoclonal antibody (mAb) that recognizes a

specific marker expression in cancer cells and directs MMAE to the cancer cells. The linker linking MMAE

to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the

antibody-drug-conjugate/ADC has bound to the specific cancer cell antigen and entered the cancer cell,

thus releasing the toxic MMAE and activating the potent anti-mitotic mechanism.