WYE125132 supplier|cas 1144068-46-1 |DC Chemicals|Supplier|Price|Buy  

WYE125132 supplier|cas 1144068-46-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: WYE125132 supplier,cas 1144068-46-1, Cat No. DC5088, In stock

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Product name: WYE125132, Synonym:　WYE-125132,WYE 125132, Cat No. DC5088, Cas: 1144068-46-1, Chemical Name:N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea, Molecular Formula: C27H33N7O4, MW: 519.6

WYE125132,cas 1144068-46-1, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. WYE125132 is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor

WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. WYE-125132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. WYE-125132 causes pre-tRNA Leu synthesis reduction by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively as a result of the inhibition of mTORC1. WYE-125132 induces Maf1 dephosphorylation and its accumulation in the nucleus.