SNX-2112 (PF-04928473) supplier|cas 908112-43-6 |DC Chemicals|Supplier|Price|Buy  

SNX-2112 (PF-04928473) supplier|cas 908112-43-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: SNX-2112 (PF-04928473) supplier,cas 908112-43-6, Cat No. DC5133, In stock

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Product name: SNX-2112 (PF-04928473), Synonym:　SNX-2112; PF 04928473, Cat No. DC5133, Cas: 908112-43-6, Chemical Name:4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide, Molecular Formula: C23H27F3N4O3, MW: 464.48

SNX-2112 (PF-04928473),cas 908112-43-6, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.

SNX-2112 is an Hsp90 inhibitor which is currently undergoing multiple phase 1 clinical trials. In all cell lines, SNX-2112 led to degradation of MET, HER-2, EGFR, and AKT as well as abrogation of Ras/Raf/MEK/MAPK and PI3K/AKT signaling, followed by complete cell cycle arrest.