Dabrafenib (GSK2118436) supplier|cas 1195765-45-7 |DC Chemicals|Supplier|Price|Buy  

Dabrafenib (GSK2118436) supplier|cas 1195765-45-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Dabrafenib (GSK2118436) supplier,cas 1195765-45-7, Cat No. DC5149, In stock

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Product name: Dabrafenib (GSK2118436), Synonym:　GSK2118436A (Dabrafenib).   GSK-2118436B (Dabrafenib Mesylate), Cat No. DC5149, Cas: 1195765-45-7, Chemical Name:N/A, Molecular Formula: C23H20F3N5O2S2, MW: 519.56

Dabrafenib (GSK2118436),cas 1195765-45-7, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3.

Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.