Rucaparib (AG-14699, PF-01367338) supplier|cas 459868-92-9 |DC Chemicals|Supplier|Price|Buy  

Rucaparib (AG-14699, PF-01367338) supplier|cas 459868-92-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Rucaparib (AG-14699, PF-01367338) supplier,cas 459868-92-9, Cat No. DC5151, In stock

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Product name: Rucaparib (AG-14699, PF-01367338), Synonym:　AG-14699 (as phosphate salt), AG-014447 (as free base); Rucaparib; PF-01367338;  AG014699;, Cat No. DC5151, Cas: 459868-92-9, Chemical Name:N/A, Molecular Formula: C19H18FN3O.H3PO4, MW: 421.36

Rucaparib (AG-14699, PF-01367338),cas 459868-92-9, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM with binding affinity to nine PARP domains. Phase 1/2.

Rucaparib (AG-14699 or PF-01367338)  is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks.