SB-71599 (Ispinesib29) supplier|cas 336113-53-2 |DC Chemicals|Supplier|Price|Buy  

SB-71599 (Ispinesib29) supplier|cas 336113-53-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: SB-71599 (Ispinesib29) supplier,cas 336113-53-2, Cat No. DC5107, In stock

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Product name: SB-71599 (Ispinesib29), Synonym:　Ispinesib29;SB-71599, Cat No. DC5107, Cas: 336113-53-2, Chemical Name:N/A, Molecular Formula: C30H33ClN4O2, MW: 517.06

SB-71599 (Ispinesib29),cas 336113-53-2, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively.

Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. Ispinesib (SB 715992) has cytotoxic activity at less than 10 nM in a spectrum of tumor cell lines. Ispinesib (SB 715992) is negative in a mouse model of peripheral neuropathy in which paclitaxel is positive. Ispinesib (SB 715992) was shown to have activity against advanced human colon tumor xenografts including: Colo205 (complete regressi), Colo201 (complete regressi), and HT-29 (tumor growth delay). Ispinesib (SB 715992) (10 mg/kg) induced unexplained toxicity in mice bearing osteosarcoma xenografts. Ispinesib (SB 715992) enhanced the antitumor activity of trastuzumab, lapatinib, doxorubicin, and capecitabine and exhibited activity comparable with paclitaxel and ixabepilone.