PD 98059 supplier|cas 167869-21-8 |DC Chemicals|Supplier|Price|Buy  

PD 98059 supplier|cas 167869-21-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PD 98059 supplier,cas 167869-21-8, Cat No. DC5100, In stock

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Product name: PD 98059, Synonym:　PD-98059,PD98059, Cat No. DC5100, Cas: 167869-21-8, Chemical Name:;2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE;2-(2-AMINO-3-METHOXY-PHENYL)CHROMEN-4-ONE;2'-AMINO-3'-METHOXYFLAVONE, Molecular Formula: C16H13NO3, MW: 267.28

PD 98059,cas 167869-21-8, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. PD 98059 is a selective inhibitor of MEK and blocker of MAPK

PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1 (MAPKK1 or MAPKs ) that binds to the inactive form of MEK-1 blocking MEK-1 activation leading to inhibition of phosphorylation and the activation of MAP kinase. In PC12 pheochromocytoma cells at an IC50= 2 μM, it produced complete blockage of any increase in MAPK activity produced by nerve growth factor. It has been shown to enhance self-renewal of embryonic stem cells and has been used to unravel the role of the MAPK cascade in biological systems. The compound has been reported to induce GSTA2 (glutathione S-transferase A2) production in H4IIE cells. PD 98059 has also been shown to enhance insulin-mediated increase in glutathione levels as well as, independent of MEK1 inhibition, elevate primary cultured rat hepatocyte glutathione levels.