AEE-788 (NVP-AEE788) supplier|cas 497839-62-0 |DC Chemicals|Supplier|Price|Buy

AEE-788 (NVP-AEE788) supplier|cas 497839-62-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: AEE-788 (NVP-AEE788) supplier,cas 497839-62-0, Cat No. DC5113, In stock

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Product name: AEE-788 (NVP-AEE788), Synonym:　AEE788, Cat No. DC5113, Cas: 497839-62-0, Chemical Name:(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Molecular Formula: C27H32N6, MW: 440.58

AEE-788 (NVP-AEE788),cas 497839-62-0, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.

AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis.