RN486 supplier|cas 1242156-23-5 |DC Chemicals|Supplier|Price|Buy  

RN486 supplier|cas 1242156-23-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: RN486 supplier,cas 1242156-23-5, Cat No. DC5146, In stock

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Product name: RN486, Synonym:　RN486; RN-486; RN 486, Cat No. DC5146, Cas: 1242156-23-5, Chemical Name:N/A, Molecular Formula: C35H35FN6O3, MW: 606.69

RN486,cas 1242156-23-5, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor.

RN486 is a Bruton's tyrosine kinase (Btk) inhibitor. RN486 not only potently and selectively inhibited the Btk enzyme, but also displayed functional activities in human cell-based assays in multiple cell types, blocking Fcε receptor cross-linking-induced degranulation in mast cells (IC(50) = 2.9 nM), Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes (IC(50) = 7.0 nM), and B cell antigen receptor-induced expression of an activation marker, CD69, in B cells in whole blood (IC(50) = 21.0 nM).