SC-560|cas 188817-13-2| DC Chem|Supplier|Price|Buy  

SC-560|cas 188817-13-2| DC Chem|Supplier|Price|Buy

DC Chemicals Supply: SC-560|cas 188817-13-2,Purity: >98% ,Cat No. DC7030, In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-61454686;Fax:+86-21-61642499；

SC-560|cas 188817-13-2 ,Synonym: SC-560,SC 560 ,Chemical name:  5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)pyrazole ,Molecular Formula:  C17H12ClF3N2O ,MW:352.73819

SC-560, cas 188817-13-2,Purity: >98%, Best Price and quality from DC Chemicals. SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex?) and rofecoxib (Vioxx?). 

SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex?) and rofecoxib (Vioxx?). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 ?M.1 Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process.2 In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor.3 The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.