2014年9月23日星期二

R406 free base |cas 841290-81-1 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: R406 free base ,cas 841290-81-1, Cat No. DC1014, In stock
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Product name: R406 free base, Synonym: R406,R-406, Cat No. DC1014, Cas: 841290-81-1, Chemical Name:6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one benzenesulfonate, Molecular Formula: C22H23FN6O5.C6H6O3S, MW: 628.63
R406 free base Cas#841290-81-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! R406 is a potent Syk inhibitor with IC50 of 41 nM and also potently inhibits Flt3.
For the detailed information about the solubility of R406 free base in water, the solubility of R406 free base in DMSO, the solubility of R406 free base in PBS buffer, the animal experiment of R406 free base,the in vivo and in vitro test of R406 free base,the cell experiment of R406 free base,the IC50 and EC50 of R406 free baseplease contact DC Chemicals.

R788 disodium (Fostamatinib) |cas 1025687-58-4 |DC Chemicals  

DC Chemials Supply: R788 disodium(Fostamatinib) ,cas 1025687-58-4, Cat No. DC1013, In stock
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Product name: R788 disodium (Fostamatinib), Synonym: R788, Fostamatinib,R-788, Cat No. DC1013, Cas: 1025687-58-4, Chemical Name:2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, sodium salt (1:2), Molecular Formula: C23H24FN6O9P.2Na, MW: 624.42
R788 disodium (Fostamatinib) Cas#1025687-58-4.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM.
Fostamatinib sodium is an orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.For the detailed information about the solubility of R788 disodium (Fostamatinib) in water, the solubility of R788 disodium (Fostamatinib) in DMSO, the solubility of R788 disodium (Fostamatinib) in PBS buffer, the animal experiment of R788 disodium (Fostamatinib),the in vivo and in vitro test of R788 disodium (Fostamatinib),the cell experiment of R788 disodium (Fostamatinib),the IC50 and EC50 of R788 disodium (Fostamatinib)please contact DC Chemicals.

Carfilzomib (PR-171) |cas 868540-17-4 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: Carfilzomib (PR-171) ,cas 868540-17-4, Cat No. DC1002, In stock.
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Product name: Carfilzomib (PR-171), Synonym: PR171, Cat No. DC1002, Cas: 868540-17-4, Chemical Name:L-Phenylalaninamide, (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-, Molecular Formula: C40H57N5O7, MW: 719.91

Carfilzomib (PR-171) Cas#868540-17-4.Purity:>99%.Best Price and Quality in the Market!Supplied byDC Chemicals! Carfilzomib (PR-171) is a proteasome inhibitor with IC50 less than 5 nM.

An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins. Inhibition of proteasome-mediated proteolysis results in an accumulation of polyubiquinated proteins, which may lead to cell cycle arrest, induction of apoptosis, and inhibition of tumor growth.
For the detailed information about the solubility of Carfilzomib (PR-171) in water, the solubility of Carfilzomib (PR-171) in DMSO, the solubility of Carfilzomib (PR-171) in PBS buffer, the animal experiment of Carfilzomib (PR-171),the in vivo and in vitro test of Carfilzomib (PR-171),the cell experiment of Carfilzomib (PR-171),the IC50 and EC50 of Carfilzomib (PR-171)please contact DC Chemicals.

SB-203580 |cas 152121-47-6 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: SB-203580 ,cas 152121-47-6, Cat No. DC1004, In stock
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Product name: SB-203580, Synonym: SB203580,SB 203580, Cat No. DC1004, Cas: 152121-47-6, Chemical Name:4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine, Molecular Formula: C21H16FN3OS, MW: 377.43

SB-203580 Cas#152121-47-6.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM.
For the detailed information about the solubility of SB-203580 in water, the solubility of SB-203580 in DMSO, the solubility of SB-203580 in PBS buffer, the animal experiment of SB-203580,the in vivo and in vitro test of SB-203580,the cell experiment of SB-203580,the IC50 and EC50 of SB-203580please contact DC Chemicals.

OSI-027 |cas 936890-98-1 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: OSI-027 ,cas 936890-98-1, Cat No. DC1006, In stock
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Product name: OSI-027, Synonym: OSI027,OSI 027, Cat No. DC1006, Cas: 936890-98-1, Chemical Name:(1r,4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[1,5-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid, Molecular Formula: C21H22N6O3, MW: 406.44
OSI-027 Cas#936890-98-1.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively.
A potent, selective and orally bioavailable mTOR inhibitor currently in clinical trial.
For the detailed information about the solubility of OSI-027 in water, the solubility of OSI-027 in DMSO, the solubility of OSI-027 in PBS buffer, the animal experiment of OSI-027,the in vivo and in vitro test of OSI-027,the cell experiment of OSI-027,the IC50 and EC50 of OSI-027please contact DC Chemicals.

Telaprevir (VX-950) |cas 402957-28-2 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: Telaprevir (VX-950) ,cas 402957-28-2, Cat No. DC1008, In stock
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Product name: Telaprevir (VX-950), Synonym: vx950,Telaprevir,VX 950, Cat No. DC1008, Cas: 402957-28-2, Chemical Name:(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)-octahydrocyclopenta[c]pyrrole-1-carboxamide, Molecular Formula: C36H53N7O6, MW: 679.85

Telaprevir (VX-950) Cas#402957-28-2.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.
VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (Ki*) of 7 nM. For the detailed information about the solubility of Telaprevir (VX-950) in water, the solubility of Telaprevir (VX-950) in DMSO, the solubility of Telaprevir (VX-950) in PBS buffer, the animal experiment of Telaprevir (VX-950),the in vivo and in vitro test of Telaprevir (VX-950),the cell experiment of Telaprevir (VX-950),the IC50 and EC50 of Telaprevir (VX-950)please contact DC Chemicals.

Laropiprant (MK-0524) |cas 571170-77-9 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: Laropiprant (MK-0524) ,cas 571170-77-9, Cat No. DC1009, In stock
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Product name: Laropiprant (MK-0524), Synonym: mk0524,Laropiprant,MK-0524, Cat No. DC1009, Cas: 571170-77-9, Chemical Name:N/A, Molecular Formula: C21H19ClFNO4S, MW: 435.901
Laropiprant (MK-0524) Cas#571170-77-9.Purity:99.85%.Best Price and Quality in the Market!Supplied by DC Chemicals! MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 ?M for the DP1 and DP2 receptors, respectively.
MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 ?M for the DP1 and DP2 receptors, respectively. It inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.For the detailed information about the solubility of Laropiprant (MK-0524) in water, the solubility of Laropiprant (MK-0524) in DMSO, the solubility of Laropiprant (MK-0524) in PBS buffer, the animal experiment of Laropiprant (MK-0524),the in vivo and in vitro test of Laropiprant (MK-0524),the cell experiment of Laropiprant (MK-0524),the IC50 and EC50 of Laropiprant (MK-0524)please contact DC Chemicals.

BIBR-1048 (Dabigatran etexilate) |cas 211915-06-9 |DC Chemicals  

DC Chemials Supply: BIBR-1048 (Dabigatran etexilate) ,cas 211915-06-9, Cat No. DC1010, In stock
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Product name: BIBR-1048 (Dabigatran etexilate), Synonym: BIBR 1048, Dabigatran etexilate,BIBR1048, Cat No. DC1010, Cas: 211915-06-9, Chemical Name:(E)-ethyl 3-(2-((4-(N'-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate, Molecular Formula: C34H41N7O5, MW: 627.73

BIBR-1048 (Dabigatran etexilate) Cas#211915-06-9.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors.
For the detailed information about the solubility of BIBR-1048 (Dabigatran etexilate) in water, the solubility of BIBR-1048 (Dabigatran etexilate) in DMSO, the solubility of BIBR-1048 (Dabigatran etexilate) in PBS buffer, the animal experiment of BIBR-1048 (Dabigatran etexilate),the in vivo and in vitro test of BIBR-1048 (Dabigatran etexilate),the cell experiment of BIBR-1048 (Dabigatran etexilate),the IC50 and EC50 of BIBR-1048 (Dabigatran etexilate)please contact DC Chemicals.

Lorcaserin |cas 616202-92-7 |DC Chemicals|Supplier|Price|Buy

DC Chemials Supply: Lorcaserin ,cas 616202-92-7, Cat No. DC1011, In stock
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Product name: Lorcaserin, Synonym: Lorcaserin, Cat No. DC1011, Cas: 616202-92-7, Chemical Name:N/A, Molecular Formula: C11H14ClN, MW: 195.692
Lorcaserin Cas#616202-92-7.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Lorcaserin (APD-356, trade name upon approval Belviq,expected trade name during development, Lorqess is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic.
Lorcaserin (APD-356, trade name upon approval Belviq,expected trade name during development, Lorqess is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic.For the detailed information about the solubility of Lorcaserin in water, the solubility of Lorcaserin in DMSO, the solubility of Lorcaserin in PBS buffer, the animal experiment of Lorcaserin,the in vivo and in vitro test of Lorcaserin,the cell experiment of Lorcaserin,the IC50 and EC50 of Lorcaserinplease contact DC Chemicals.

 

Macitentana (Actelion-1, ACT-064992) |cas 441798-33-0 |DC Chemical  

DC Chemials Supply: Macitentana (Actelion-1, ACT-064992) ,cas 441798-33-0, Cat No. DC1012, In stock
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Product name: Macitentana (Actelion-1,ACT-064992), Synonym: ACT-064992,ACT064992, Cat No. DC1012, Cas: 441798-33-0, Chemical Name:Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-, Molecular Formula: C19H20Br2N6O4S, MW: 588.27
Macitentana (Actelion-1,ACT-064992) Cas#441798-33-0.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Macitentana (Actelion-1, ACT-064992) is an orally active, non-peptide dual endothelin (ET)A/B receptor antagonist with IC50 of 0.5 nM/391 nM.
Description of Macitentan:  Macitentan is an investigational drug being studied for the treatment of pulmonary arterial hypertension. It acts as a dual endothelin receptor antagonist and is being developed by Actelion. A Phase III clinical trial was successfully completed in 2012.
For the detailed information about the solubility of Macitentana (Actelion-1, ACT-064992) in water, the solubility of Macitentana (Actelion-1, ACT-064992) in DMSO, the solubility of Macitentana (Actelion-1, ACT-064992) in PBS buffer, the animal experiment of Macitentana (Actelion-1, ACT-064992),the in vivo and in vitro test of Macitentana (Actelion-1, ACT-064992),the cell experiment of Macitentana (Actelion-1, ACT-064992),the IC50 and EC50 of Macitentana (Actelion-1, ACT-064992)please contact DC Chemicals.

FK-506 (Tacrolimus) |cas 104987-11-3 |DC Chemicals|Supplier|Price|Buy

DC Chemials Supply: FK-506 (Tacrolimus) ,cas 104987-11-3, Cat No. DC1001, In stock
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Product name: FK-506 (Tacrolimus), Synonym:Fujimycin,Prograf,FK506,TACROLIMUS, Cat No. DC1001, Cas: 104987-11-3,
Chemical Name:N/A,
Molecular Formula: C44H69NO12, MW: 804.02
FK-506 (Tacrolimus) Cas#104987-11-3.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! An immunosuppressive agent and macrolide antibiotic.
Description of Tacrolimus: Tacrolimus, also known as FK-506, is a macrolide isolated from the fungus Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of FK-506 (Tacrolimus) in water, the solubility of FK-506 (Tacrolimus) in DMSO, the solubility of FK-506 (Tacrolimus) in PBS buffer, the animal experiment of FK-506 (Tacrolimus),the in vivo and in vitro test of FK-506 (Tacrolimus),the cell experiment of FK-506 (Tacrolimus),the IC50 and EC50 of FK-506 (Tacrolimus)please contact DC Chemicals.

AMG 853(AMG853;Vidupiprant) |cas 1169483-24-2|DC Chemicals|Supplier|Price|Buy

 

DC Chemials Supply: AMG 853(AMG853;Vidupiprant) ,cas 1169483-24-2, Cat No. DC6310, In stock
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Product name: AMG 853(AMG853;Vidupiprant), Synonym: AMG-853, AMG853, Vidupiprant, Cat No. DC6310, Cas: 1169483-24-2, Chemical Name:N/A, Molecular Formula: C28H27Cl2FN2O6S, MW: 609.493183
AMG 853(AMG853;Vidupiprant), cas 1169483-24-2, Supplied by DC Chemicals,Best Price and Quality in the market. AMG 853 is novel a CRTH2 and DP Dual Antagonist.
AMG 853 is novel a CRTH2 and DP Dual Antagonist.

PSI-6206,PSI6206 |cas 863329-66-2|DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: PSI-6206PSI6206 ,cas 863329-66-2, Cat No. DC6309, In stock
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Product name: PSI6206, Synonym: PSI-6206, RO-2433, PSI6206, RO2433, Cat No. DC6309, Cas: 863329-66-2, Chemical Name:N/A, Molecular Formula: C10H13FN2O5, MW: 260.22
PSI-6206,PSI6206, cas 863329-66-2, Supplied by DC Chemicals,Best Price and Quality in the market. PSI-6206 is a selective inhibitor of hepatitis C virus (HCV).
PSI-6206 (RO2433) is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. The monophosphate form of PSI-6206 was shown to be metabolized in primary human hepatocytes to its triphosphate analog PSI-7409. Furthermore, the phosphoramidate prodrug of PSI-6206 monophosphate, PSI-7851, was developed. Alternatively, PSI-6130, an aminated analog of PSI-6206 monophosphate, was also developed. (1,2,3)

XL888|cas 1149705-71-4|DC Chemicals|Supplier|Price|Buy  

DC Chemicals Supply: XL888,cas 1149705-71-4, Cat No. DC6307, In stock
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Product name: XL888, Synonym: XL888; XL-888XL 888, Cat No. DC6307, Cas: 1149705-71-4, Chemical Name:5-((R)-sec-butylamino)-N1-((1R,3s,5S)-8-(5-(cyclopropanecarbonyl)pyridin-2-yl)-8-azabicyclo[3.2.1]octan-3-yl)-2-methylterephthalamide, Molecular Formula: C29H37N5O3, MW: 503.28964
XL888, cas 1149705-71-4, Supplied by DC Chemicals,Best Price and Quality in the market. XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.
XL888 is an orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor XL888 specifically binds to Hsp90, inhibiting its chaperone function and promoting the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; inhibition of tumor cell proliferation may result. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins, including Her-2 and Met.XL888 induces HER2 degradation in NCI-N87 cells with IC50 of 56 nM. XL888 inhibits the proliferation of HER2 over-expressed NCI-N87, HER2 over-expressed BT-474, HER2 over-expressed MDA-MB-453, MET mutated MKN45, B-Raf mutated Colo-205, B-Raf mutated SK-MEL-28, EGFR mutated HN5, EGFR mutated NCI-H1975, PI3K mutated MCF7, and K-Ras mutated A549 with IC50 of 21.8, 0.1, 16.0, 45.5, 11.6, 0.3, 5.5, 0.7, 4.1 and 4.3 nM. [1] XL888 leads to dose-dependent decreases in the growth of vemurafenib-naive and vemurafenib-resistant melanoma cell lines and melanoma cell lines with intrinsic resistance with IC50 of all around 0.1 μM. The growth inhibitory effects of XL888 are associated with induction of either a G1-phase cell-cycle arrest (WM164, M229, M229R, M249, M249R, 1205Lu, and WM39 cell lines) or a G2-M phase cell-cycle arrest (WM164R, 1205LuR, and RPMI 7951 cell lines). XL888 (300 nmol) induces high levels ( > 66%) of apoptosis, and loss of mitochondrial membrane potential (TMRM) in these cell lines. The cytotoxic effects of XL888 are durable with no signs of colony formation observed in any of the cell lines even cultured up to 4 weeks. XL888 treatment (300 nM, 48 hours) leads to the degradation of IGF1R, PDGFRβ, ARAF, CRAF, and cyclin D1 and the inhibition of AKT, ERK, and S6 signaling in all of the cell lines with acquired BRAF inhibitor resistance. treatment of cell lines that are naive, intrinsically resistant, and with acquired vemurafenib resistance. Treatment with XL888 (300 nM) leads to robust time-dependent increases in the expression of HSP70 isoform 1. XL888 (48 hours, 300 nM) treatment increases the expression of BIM-EL, BIM-L, and BIM-S expression in the M229R, 1205LuR, RPMI7951, and WM39 cell lines, induces expression of BIM-L and BIM-S in the WM164R cell line, and BIM-EL in the M249R cell line.XL888 (100 mg/kg) significantly induces the regression of, or growth inhibition (50%) of established M229R and 1205LuR xenografts in SCID mice. 15 days of XL888 treatment showes a robust (8.6-fold) increase in intratumoral HSP70 expression compared with controls. XL888 treatment is noted to be proapoptotic in vivo and leads to increased TUNEL staining in M229R xenografts associated with increased expression of BIM and decreased expression of Mcl-1.

LY2157299|cas 700874-72-2, 912477-03-3|DC Chemicals|Supplier|Price|Buy 

DC Chemials Supply: LY2157299,cas 700874-72-2, 912477-03-3, Cat No. DC6306, In stock
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Product name: LY2157299, Synonym: LY-2157299,LY 2157299, Cat No. DC6306, Cas: 700874-72-2, 912477-03-3, Chemical Name:4-[2-(6-Methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-quinoline-6-carboxylic acid amide, Molecular Formula: C22H19N5O, MW: 369.42
LY2157299, cas 700874-72-2, 912477-03-3, Supplied by DC Chemicals,Best Price and Quality in the market LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2.
LY2157299, a specific and potent TGF-β receptor (TβR) inhibitor that competitively binds to the active site of its kinase domain1, inhibiting TGF-β-mediated SMAD2 phosphorylation/activation and down streaming signaling.
LY2157299 inhibited hematopoetic suppression in primary hematopoietic stem cells, such that it improved anemia in a TGF-β overexpressing transgenic mouse model, and stimulated hematopoiesis from primary MDS bone marrow specimens2. Daily oral administration of LY2157299 in patients with advanced/metastatic cancer was tolerated well with an expected pharmacokinetic profile3,4.

LY364947|cas 396129-53-6|DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: LY364947,cas 396129-53-6, Cat No. DC6305, In stock

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Product name: LY364947, Synonym: LY 364947,LY-364947, Cat No. DC6305, Cas: 396129-53-6, Chemical Name:N/A, Molecular Formula: C17H12N4, MW: 272.3
LY364947, cas 396129-53-6, Supplied by DC Chemicals,Best Price and Quality in the market ,LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, shows 7-fold selectivity over TGFβR-II.
LY364947 is an ATP competitive and tight-binding inhibitor, inhibiting phosphorylation of P-Smad3 by TGFβR-I kinase with Ki of 28 nM. LY364947 inhibits in vivo Smad2 phosphorylation within the NMuMg cells with IC50 of 135 nM. LY364947 reverses TGF-β-mediated growth inhibition in NMuMg cells with IC50 of 0.218 μM. LY364947 potentiates the xVent2-lux BMP4 response in NMuMg cells by 30% at concentrations as low as 0.25 μM. LY364947 (2 μM) prevents TGF-β-induced epithelial?mesenchymal transition in NMuMg cells. LY364947 (3 μM) induces expression of Prox1 and LYVE-1 in almost all HDLECs after 24 hours.LY364947 promotes nuclear export of Foxo3a, with low Smad2/3 and high Akt phosphorylation levels in leukaemia-initiating cells. LY364947 (< 20 μM) suppresses leukaemia-initiating cells colony-forming ability after co-culture with OP-9 stromal cells.LY364947 (1 mg/kg i.p.) accelerates lymphangiogenesis, as evidence by significantly increased the LYVE-1-positive areas, in a mouse model of chronic peritonitis. LY364947 (1 mg/kg i.p.) significantly increases the LYVE-1-positive areas in tumor tissues in tumor xenograft models using BxPC3 pancreatic adenocarcinoma cells. [4] LY364947 (25?mg?/kg) increases p-Akt and decreases nuclear Foxo3a in leukaemia-initiating cells in CML-affected mice.