Laropiprant (MK-0524) |cas 571170-77-9 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: Laropiprant (MK-0524) ,cas 571170-77-9, Cat No. DC1009, In stock

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Product name: Laropiprant (MK-0524), Synonym:　mk0524,Laropiprant,MK-0524, Cat No. DC1009, Cas: 571170-77-9, Chemical Name:N/A, Molecular Formula: C21H19ClFNO4S, MW: 435.901

Laropiprant (MK-0524) Cas#571170-77-9.Purity:99.85%.Best Price and Quality in the Market!Supplied by DC Chemicals! MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 ?M for the DP1 and DP2 receptors, respectively.

MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 ?M for the DP1 and DP2 receptors, respectively. It inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.For the detailed information about the solubility of Laropiprant (MK-0524) in water, the solubility of Laropiprant (MK-0524) in DMSO, the solubility of Laropiprant (MK-0524) in PBS buffer, the animal experiment of Laropiprant (MK-0524),the in vivo and in vitro test of Laropiprant (MK-0524),the cell experiment of Laropiprant (MK-0524),the IC50 and EC50 of Laropiprant (MK-0524)please contact DC Chemicals.