CHIR258 |cas:405169-16-6 |DC Chemicals|Supplier|Price|Buy  

CHIR258 |cas 405169-16-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: CHIR258 ,cas 405169-16-6, Cat No. DC4157, In stock

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Product name: CHIR258, Synonym:　CHIR-258,CHIR 258, Cat No. DC4157, Cas: 405169-16-6, Chemical Name:1-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one, Molecular Formula: C21H21FN6O, MW: 392.43

CHIR258 Cas#405169-16-6.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

CHIR-265 is an orally bioavailable small molecule with potential antineoplastic activity.CHIR-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

For the detailed information about the solubility of CHIR258 in water, the solubility of CHIR258 in DMSO, the solubility of CHIR258 in PBS buffer, the animal experiment of CHIR258,the in vivo and in vitro test of CHIR258,the cell experiment of CHIR258,the IC50 and EC50 of CHIR258please contact DC Chemicals.