BGJ398 (NVP-BGJ398) supplier|cas 872511-34-7 |DC Chemicals|Supplier|Price|Buy 

DC Chemials Supply: BGJ398 (NVP-BGJ398) supplier,cas 872511-34-7, Cat No. DC5194, In stock

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Product name: BGJ398 (NVP-BGJ398), Synonym:　NVP-BGJ398, BGJ398, BG-J398, Cat No. DC5194, Cas: 872511-34-7, Chemical Name:3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea., Molecular Formula: C26H31Cl2N7O3, MW: 560.47

BGJ398 (NVP-BGJ398),cas 872511-34-7, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.

BGJ398 is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.