HC-030031 |cas 349085-38-7 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: HC-030031 ,cas 349085-38-7, Cat No. DC5200, In stock

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Product name: HC-030031, Synonym:　HC030031, HC 030031, Cat No. DC5200, Cas: 349085-38-7, Chemical Name:N/A, Molecular Formula: C18H21N5O3, MW: 355.39

HC-030031,cas 349085-38-7, Purity:>98%, Best price and quality from DC Chemicals. HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

In vitro: HC-030031 is a substituted theophylline derivative. Potent and selective TRPA1 inhibitor. HC-030031 can block both inward and outward currents elicited by AITC or formalin rapidly and reversibly and also blocks the activation of TRPA1 by N-methylmaleimide and by electrophillic prostaglandins. It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channels. In vivo:HC-030031 can be delivered to animals orally, by inhalation, or by injection. Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 μg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity.