ROSCOVITINE |cas 186692-46-6 |DC Chemicals|Supplier|Price|Buy

ROSCOVITINE |cas 186692-46-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: ROSCOVITINE ,cas 186692-46-6, Cat No. DC4124, In stock

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Product name: ROSCOVITINE, Synonym:　N/A, Cat No. DC4124, Cas: 186692-46-6, Chemical Name:(R)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol, Molecular Formula: C19H26N6O, MW: 354.45

ROSCOVITINE Cas#186692-46-6.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively.

Description of Seliciclib: Seliciclib is an orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Mcl-1 belongs to the Bcl-2 family of antiapoptotic proteins and is a protein crucial to the survival of a range of tumor cell types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

For the detailed information about the solubility of ROSCOVITINE in water, the solubility of ROSCOVITINE in DMSO, the solubility of ROSCOVITINE in PBS buffer, the animal experiment of ROSCOVITINE,the in vivo and in vitro test of ROSCOVITINE,the cell experiment of ROSCOVITINE,the IC50 and EC50 of ROSCOVITINEplease contact DC Chemicals.