Ivacaftor (VX-770) |cas 873054-44-5 |DC Chemicals|Supplier|Price|Buy  

Ivacaftor (VX-770) |cas 873054-44-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Ivacaftor (VX-770) ,cas 873054-44-5, Cat No. DC4128, In stock

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Product name: Ivacaftor (VX-770), Synonym:　vx770, Cat No. DC4128, Cas: 873054-44-5, Chemical Name:N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide, Molecular Formula: C24H28N2O3, MW: 392.49

Ivacaftor (VX-770) Cas#873054-44-5.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.

Description of Ivacaftor: Ivacaftor (VX-770) is an experimental drug candidate for the treatment of cystic fibrosis, currently under development by Vertex Pharmaceuticals and the Cystic Fibrosis Foundation. The drug is designed to be effective in patients that have the G551D mutation in the defective protein that causes the disease. G551D, meaning that the amino acid glycine in position 551 is substituted with aspartic acid, is only found in a small percentage of cystic fibrosis patients. The drug is currently in Phase 3 clinical trials and has showed promising results for this subset of patients. Cystic fibrosis is caused by a defect in a protein, cystic fibrosis transmembrane conductance regulator, which regulates fluid flow within cells and affects the components of sweat, digestive fluids, and mucus. VX-770 potentiates the effect of the defective protein to restore a more normal function. (source:http://en.wikipedia.org/wiki/Ivacaftor ).

For the detailed information about the solubility of Ivacaftor (VX-770) in water, the solubility of Ivacaftor (VX-770) in DMSO, the solubility of Ivacaftor (VX-770) in PBS buffer, the animal experiment of Ivacaftor (VX-770),the in vivo and in vitro test of Ivacaftor (VX-770),the cell experiment of Ivacaftor (VX-770),the IC50 and EC50 of Ivacaftor (VX-770)please contact DC Chemicals.