LY2157299|cas 700874-72-2, 912477-03-3|DC Chemicals|Supplier|Price|Buy 

DC Chemials Supply: LY2157299,cas 700874-72-2, 912477-03-3, Cat No. DC6306, In stock

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Product name: LY2157299, Synonym:　LY-2157299,LY 2157299, Cat No. DC6306, Cas: 700874-72-2, 912477-03-3, Chemical Name:4-[2-(6-Methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-quinoline-6-carboxylic acid amide, Molecular Formula: C22H19N5O, MW: 369.42

LY2157299, cas 700874-72-2, 912477-03-3, Supplied by DC Chemicals,Best Price and Quality in the market LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2.

LY2157299, a specific and potent TGF-β receptor (TβR) inhibitor that competitively binds to the active site of its kinase domain1, inhibiting TGF-β-mediated SMAD2 phosphorylation/activation and down streaming signaling.

LY2157299 inhibited hematopoetic suppression in primary hematopoietic stem cells, such that it improved anemia in a TGF-β overexpressing transgenic mouse model, and stimulated hematopoiesis from primary MDS bone marrow specimens2. Daily oral administration of LY2157299 in patients with advanced/metastatic cancer was tolerated well with an expected pharmacokinetic profile3,4.