TIC10 supplier|cas 41276-02-2 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: TIC10 supplier,cas 41276-02-2, Cat No. DC5192, In stock

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Product name: TIC10, Synonym:　TIC-10; TIC 10; TIC10, Cat No. DC5192, Cas: 41276-02-2, Chemical Name:7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one, Molecular Formula: C24H26N4O, MW: 386.48944

TIC10,cas 41276-02-2, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics.

TIC-10 (or TIC10) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.