OG-L002 | CAS 1357302-64-7|DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: OG-L002 , CAS 1357302-64-7, Cat No. DC5204, In stock

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Product name: OG-L002, Synonym:　OGL002,OG L002,OGL-002, Cat No. DC5204, Cas: 1357302-64-7, Chemical Name:[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o, Molecular Formula: C15H15NO, MW: 225.29

OG-L002, CAS 1357302-64-7, Purity:99%, Best price and quality from DC Chemicals. Plinabulin (NPI-2358) is a vascular disrupting agents (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 2.

OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene.OG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model.