EPZ004777 supplier|cas 1338466-77-5 |DC Chemicals|Supplier|Price|Buy  

DC Chemials Supply: EPZ004777 supplier,cas 1338466-77-5, Cat No. DC5182, In stock

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Product name: EPZ004777, Synonym:　EPZ004777; EPZ 004777; EPZ-004777, Cat No. DC5182, Cas: 1338466-77-5, Chemical Name:1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, Molecular Formula: C28H41N7O4, MW: 539.67

EPZ004777,cas 1338466-77-5, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.

EPZ004777 is a potent, selective inhibitor of DOT1L. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non-MLL-translocated cells. Finally, in vivo administration of EPZ004777 leads to extension of survival in a mouse MLL xenograft model. These results provide compelling support for DOT1L inhibition as a basis for targeted therapeutics against MLL.