PHA-793887 |cas 718630-59-2 |DC Chemicals|Supplier|Price|Buy  

PHA-793887 |cas 718630-59-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PHA-793887 ,cas 718630-59-2, Cat No. DC4123, In stock

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Product name: PHA-793887, Synonym:　PHA793887,PHA 793887, Cat No. DC4123, Cas: 718630-59-2, Chemical Name:N-(6,6-dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide, Molecular Formula: C19H31N5O2, MW: 361.48

PHA-793887 Cas#718630-59-2.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively.

Description of PHA-793887: PHA-793887 is an inhibitor of multiple cyclin dependent kinases (CDK) with activity against CDK2, CDK1 and CDK4. Although toxicity was acceptable at initial dose levels, PHA-793887 was poorly tolerated at doses ≥44 mg/m2. The most frequent events across all dose levels were gastrointestinal or nervous system events. PHA-793887 induces severe, dose-related hepatic toxicity, which was not predicted by pre-clinical models and currently precludes its further clinical development. (source: Cell Cycle. 2011 Mar 15;10(6):963-70.).

For the detailed information about the solubility of PHA-793887 in water, the solubility of PHA-793887 in DMSO, the solubility of PHA-793887 in PBS buffer, the animal experiment of PHA-793887,the in vivo and in vitro test of PHA-793887,the cell experiment of PHA-793887,the IC50 and EC50 of PHA-793887please contact DC Chemicals.