KX2-391|KX2-391|Src inhibitor|cas 897016-82-9

KX2-391|KX2-391|Src inhibitor|cas 897016-82-9

DC Chemicals, Website: www.dcchemicals.com

Product Name: KX2-391|Cas Number: 897016-82-9| Catalog Number: DC10608|Other Nmaes: KX2-391,KX2 391,KX2391

KX2-391, the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.

KX2-391 is a Src inhibitor that is directed to the Src substrate pocket. KX2-391 shows steep dose-response curves against Huh7 (GI 50 = 9 nM), PLC/PRF/5 (GI 50 = 13 nM), Hep3B (GI 50 = 26 nM), and HepG2 (GI 50 = 60 nM), four hepatic cell cancer (HCC) cell lines.KX2-391 is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. KX2-391 is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively.

JTE-013|JTE013|S1P2 antagonist|cas 944547-46-0

JTE-013|JTE013|S1P2 antagonist|cas 944547-46-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: JTE-013|Cas Number: 383150-41-2| Catalog Number: DC10607|Other Nmaes: JTE-013,JTE 013,JTE013

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

JTE-013 reverses the inhibitory effects of S1P2 signaling on cell migration of vascular ECs and smooth muscle cells. It regulates endothelial tight junctions and barrier function in vitro. Blockage of S1P2 signaling by JTE-013 significantly enhances the effects of S1P on the increase of TEER, an in vitro measurement of endothelial integrity, as well as the formation of TJs in senescent ECs.JTE-013 inhibition of S1P2 significantly inhibits microvascular permeability in an in vivo animal model. JTE-013 modulates the responses of brain endothelium by inhibiting cerebrovascular permeability, the development of intracerebral heamorrhage, and neurovascular injury in an experimental model of stroke. JTE-013 reduced mast cell activation, airway infiltration, and the serum levels of histamine and several cytokines in vitro and in vivo studies. In a murine model, JTE-013 suppresses streptozotocin-induced blood glucose increases, pancreatic b cell apoptosis, and the incidence of diabetes. In a New Zealand obese diabetic mouse model under high-fat diet conditions, it protected pancreatic b cells. Treatment with JTE-013 also reduces plasma levels of IL-1b and IL-18 (endotoxin-induced inflammatory cytokines) in ApoE−/− mice and S1P2 gene deficiency reduces atherosclerosis. The compound offers a novel means of treating inflammatory disorders, such as, atherosclerosis and sepsis.

Mycro-3 |cas 944547-46-0

Mycro-3 |cas 944547-46-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: Mycro-3 |Cas Number: 944547-46-0| Catalog Number: DC10606

Mycro 3 is potent and selective for c-Myc in whole cell assays.

Mycro 3 is potent and selective for c-Myc in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1), Mycro 3 has a superior specificity profile to its predecessors. Mycro 3 inhibits the interaction between c-Myc and Max. Mycro 3 has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA.

Brevianamide F|cas 38136-70-8

Brevianamide F|cas 38136-70-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: Brevianamide F|Cas Number: 38136-70-8| Catalog Number: DC10605

Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.

Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F possess interesting breast cancer resistance protein inhibitory activity.brevianamide F once used as aromatic substrate.

PARGYLINE HYDROCHLORIDE|cas 306-07-0

PARGYLINE HYDROCHLORIDE|cas 306-07-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: PARGYLINE HYDROCHLORIDE|Cas Number: 306-07-0| Catalog Number: DC10604|Other Nmaes: NSC 43798

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO; Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively).

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO; Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively).At 10 mg/kg i.v., pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Dawley rats.The correlation between the fall of blood pressure and the inhibition of brain MAO suggests that the accumulation of amine in brain is responsible for the fall in pressure.Reactive oxygen species-mediated monocyte hypertrophy is prevented by pargyline at a concentration of 10 µM.Formulations containing pargyline have been used to treat moderate hypertension.

NSC 247030|cas 114727-43-4

NSC 247030|cas 114727-43-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: NSC 247030|Cas Number: 114727-43-4| Catalog Number: DC10603|Other Nmaes: NSC247030,NSC-247030,NSC 247030

NSC 247030 is a bioactive chemical.

SU 4313|cas 186611-55-2

SU 4313|cas 186611-55-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: SU 4313|Cas Number: 186611-55-2| Catalog Number: DC10602|Other Nmaes: SU4313 SU-4313 SU 4313

SU 4313 is a bioactive chemical.

SU 4942|cas 76086-99-2

SU 4942|cas 76086-99-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: SU 4942|Cas Number: 76086-99-2| Catalog Number: DC10601|Other Nmaes: SU 4942; SU-4942; SU4942

SU 4942 is a bioactive chemical.

SU 5205|cas 3476-86-6

SU 5205|cas 3476-86-6

DC Chemicals, Website: www.dcchemicals.com

Product Name: SU 5205|Cas Number: 3476-86-6| Catalog Number: DC10600|Other Nmaes: SU 5205; SU-5205; SU5205

SU 5205 is a VEGFR2 inhibitor.

NSC 409012|cas 90947-00-5

NSC 409012|cas 90947-00-5

DC Chemicals, Website: www.dcchemicals.com

Product Name: NSC 409012|Cas Number: 90947-00-5| Catalog Number: DC10599

NSC 409012 is a bioactive chemical.

lavendustin A|cas 125697-92-9

lavendustin A|cas 125697-92-9

DC Chemicals, Website: www.dcchemicals.com

Product Name: lavendustin A|Cas Number: 125697-92-9| Catalog Number: DC10598|Other Nmaes: RG-14355,NSC 678027

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate.

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 µM).2 It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.

lavendustin B|cas 125697-91-8

lavendustin B|cas 125697-91-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: lavendustin B|Cas Number: 125697-91-8| Catalog Number: DC10597

Lavendustin B is a Tyrosine Kinase Inhibitor amd an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).

Lavendustin B is a Tyrosine Kinase Inhibitor amd an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).

Lavendustin C (HDBA)|cas 125697-93-0

Lavendustin C (HDBA)|cas 125697-93-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: Lavendustin C (HDBA)|Cas Number: 125697-93-0| Catalog Number: DC10596|Other Nmaes: NSC 666251

HDBA, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 µM.

HDBA is a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 µM.HDBA also inhibits pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II with IC50 values of 0.5 and 0.2 µM, respectively.At a concentration of 10-150 µM, HDBA inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.

JK-P3|cas 942655-44-9

JK-P3|cas 942655-44-9

DC Chemicals, Website: www.dcchemicals.com

Product Name: JK-P3|Cas Number: 942655-44-9| Catalog Number: DC10595

JK-P3 is a VEGFR-2 inhibitor.

JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50 = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.

Tolcide 2230|cas 21564-17-0

Tolcide 2230|cas 21564-17-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: Tolcide 2230|Cas Number: 21564-17-0| Catalog Number: DC10594|Other Nmaes: Benthiazole; Superdavloxan; TCMTB

An antimicrobial agent used as a substitute for chlorophenols

CPI-455 analogue(KDM5 inhibitor)|cas N/A

CPI-455 analogue(KDM5 inhibitor)|cas N/A

DC Chemicals, Website: www.dcchemicals.com

Product Name: CPI-455 analogue(KDM5 inhibitor)|Cas Number: N/A| Catalog Number: DC10593

CPI-455 analogue is a selective inhibitor of KDM5 demethylases.

ASL 601(Acecainide)|cas 34118-92-8

ASL 601(Acecainide)|cas 34118-92-8

DC Chemicals, Website: www.dcchemicals.com

Product Name:  ASL 601(Acecainide)|Cas Number: 34118-92-8| Catalog Number: DC10592|Other Nmaes: Acecainide; N-acetylprocainamide, ASL 601; ASL-601; ASL601

Acecainide, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide.

Acecainide, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide. Acecainide is a Class III antiarrhythmic agent. It can be given either intravenously or orally, and is eliminated primarily by renal excretion.

CPI-613|cas 95809-78-2

CPI-613|cas 95809-78-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: CPI-613|Cas Number: 95809-78-2| Catalog Number: DC10591|Other Nmaes: CPI-613,CPI 613,CPI613

CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer.

CPI-613 is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. CPI-613 has been granted orphan drug status by the US FDA for pancreatic cancer.

Gemcitabine monophosphate|cas 1638288-31-9

Gemcitabine monophosphate|cas 1638288-31-9

DC Chemicals, Website: www.dcchemicals.com

Product Name: Gemcitabine monophosphate|Cas Number: 1638288-31-9| Catalog Number: DC10590|Other Nmaes: Gemcitabine monophosphate disodium salt monohydrate; Gemcitabine monophosphate disodium; GemMP

Gemcitabine monophosphate disodium salt, also called GemMP, is a monophosphate derivative of Gemcitabine.

Gemcitabine monophosphate disodium salt, also called GemMP, is a monophosphate derivative of Gemcitabine. Gemcitabine (Gem) is a deoxycytidine analog that is effective against pancreatic cancer and other malignancies following conversion to the 5'-O-mono-, di- and tri-phosphate forms. GemMP decreased tumor cell growth at concentrations ranging from 1 to 50 nM. GemMP is a potent cytotoxic agent that serves to induce apoptosis in association with increased Fas expression in cultured thyroid cancer cell lines.

AG 1406|cas 71308-34-4

AG 1406|cas 71308-34-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: AG 1406|Cas Number: 71308-34-4| Catalog Number: DC10589|Other Nmaes: AG1406,AG-1406

AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2

ASP-9521 |cas 1126084-37-4

ASP-9521 |cas 1126084-37-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: ASP-9521 |Cas Number: 1126084-37-4| Catalog Number: DC10588|Other Nmaes: ASP9521; ASP-9521; ASP 9521. AKR1C3 inhibitor ; 17HSD5 inhibitor

ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.

ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). ASP9521 has demonstrated anti-tumour activity in in vitro and in vivo preclinical models. ASP9521 inhibited conversion of androstenedione (AD) into testosterone (T) by recombinant human or cynomolgus monkey AKR1C3 in a concentration-dependent manner (IC50,human: 11 nmol/L; IC50,monkey: 49 nmol/L). ASP9521 showed >100-fold selectivity for AKR1C3 over the isoform AKR1C2. In LNCaP-AKR1C3 cells, ASP9521 suppressed AD-dependent PSA production and cell proliferation. In patients with mCRPC, ASP9521 demonstrated dose-proportional increase in exposure over the doses evaluated, with an acceptable safety and tolerability profile. However, the novel androgen biosynthesis inhibitor showed no relevant evidence of clinical activity.

ASP-9521 |cas 1126084-37-4

ASP-9521 |cas 1126084-37-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: ASP-9521 |Cas Number: 1126084-37-4| Catalog Number: DC10588|Other Nmaes: ASP9521; ASP-9521; ASP 9521. AKR1C3 inhibitor ; 17HSD5 inhibitor

ASP-9521 is a potent, selective and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3.

ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). ASP9521 has demonstrated anti-tumour activity in in vitro and in vivo preclinical models. ASP9521 inhibited conversion of androstenedione (AD) into testosterone (T) by recombinant human or cynomolgus monkey AKR1C3 in a concentration-dependent manner (IC50,human: 11 nmol/L; IC50,monkey: 49 nmol/L). ASP9521 showed >100-fold selectivity for AKR1C3 over the isoform AKR1C2. In LNCaP-AKR1C3 cells, ASP9521 suppressed AD-dependent PSA production and cell proliferation. In patients with mCRPC, ASP9521 demonstrated dose-proportional increase in exposure over the doses evaluated, with an acceptable safety and tolerability profile. However, the novel androgen biosynthesis inhibitor showed no relevant evidence of clinical activity.

SPI 112 |cas 1051387-90-6

SPI 112 |cas 1051387-90-6

DC Chemicals, Website: www.dcchemicals.com

Product Name: SPI 112 |Cas Number: 1051387-90-6| Catalog Number: DC10587|Other Nmaes: SPI-112;SPI112

SPI 112 is novel Shp2 PTP inhibitor.

KDM4D-IN-1|cas 2098902-68-0

KDM4D-IN-1|cas 2098902-68-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: KDM4D-IN-1|Cas Number: 2098902-68-0| Catalog Number: DC10586

KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.

KDM4D-IN-1 (Compound 10r) is the most potent one with an IC50 value of 0.41±0.03 μM against KDM4D. KDM4D-IN-1 displays almost no activity against KDM2B, KDM3B, and KDM5A (IC50>10 μM), indicating that KDM4D-IN-1 has a good selectivity for KDM4D against other selected KDMs.

Hispidol|cas 5786-54-9

Hispidol|cas 5786-54-9

DC Chemicals, Website: www.dcchemicals.com

Product Name: Hispidol|Cas Number: 5786-54-9| Catalog Number: DC10585|Other Nmaes: NSC356828

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM.

Hispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression.
The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner.

IRAK4-IN-1 |cas 1820787-94-7

IRAK4-IN-1 |cas 1820787-94-7

DC Chemicals, Website: www.dcchemicals.com

Product Name: IRAK4-IN-1 |Cas Number: 1820787-94-7| Catalog Number: DC10584

IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.

The in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB).
Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance (Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h.

RO 5028442|cas 920022-47-5

RO 5028442|cas 920022-47-5

DC Chemicals, Website: www.dcchemicals.com

Product Name: RO 5028442|Cas Number: 920022-47-5| Catalog Number: DC10583|Other Nmaes: RO-5028442; RO 5028442; RO5028442

RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).

Compounds 29, 31, and RO5028442 (compound 8) have excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. All compounds show high solubility. RO5028442 is found to be highly selective against a panel of 89 targets. Finally, RO5028442 is identified as a suitable compound for clinical studies.

Diroximel Fumarete(ALKS-8700) |cas 1577222-14-0

Diroximel Fumarete(ALKS-8700) |cas 1577222-14-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: Diroximel Fumarete(ALKS-8700) |Cas Number: 1577222-14-0| Catalog Number: DC10582|Other Nmaes: Diroximel fumarate; ALKS8700; ALKS 8700; ALKS-8700;2-(2,5-dioxopyrrolidin-1-yl)ethyl methyl fumarate

ALKS-8700 also known as diroximel fumarate,  is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body.

Succinobucol（AGI 1067)|cas 216167-82-7

Succinobucol（AGI 1067)|cas 216167-82-7

DC Chemicals, Website: www.dcchemicals.com

Product Name: Succinobucol（AGI 1067)|Cas Number: 216167-82-7| Catalog Number: DC10581|Other Nmaes: Succinobucol; AGI-1067; AGZ-1067; AGI1067; AGZ1067. Probucol monosuccinae

Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects.

Succinobucol (10, 50, 100 μM) causes a dose-dependent reduction in collagen-induced platelet aggregation in rabbit whole blood. Succinobucol also causes a significant reduction in whole blood aggregation in response to ADP. Succinobucol (10, 100 μM) significantly lowers the relaxation to X/XO. Succinobucol significantly prevents 3-NP-induced loss of SH-SY5Y cell viability, generation of reactive oxygen species, and decrease of ΔΨm. Succinobucol does not protect against 3-NP-induced inhibition of mitochondrial complex II activity, pointing to the mitigation of secondary events resultant from mitochondrial complex II inhibition. Succinobucol significantly increases (50 %) the levels of GSH in SH-SY5Y cells, which is paralleled by significant increases in glutamate cysteine ligase messenger RNA (mRNA) expression and activity. Succinobucol effectively exhibits superior inhibitory effects on cell migration and invasion activities, VCAM-1 expression and cell-cell binding of RAW 264.7 to 4T1 cells. Succinobucol also shows inhibitory effect on VCAM-1 expression in 4T1 cells and cell-cell binding of RAW 264.7 to 4T1 cancer cells.
Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP, but the blood removed 15 minutes after the final injection of succinobucol shows significantly less aggregation in response to collagen at both 5 µg/mL and 20 µg/mL in rats. Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules in lung metastatic breast cancer mice[3].

hVEGF-IN-1|cas 1637443-98-1

hVEGF-IN-1|cas 1637443-98-1

DC Chemicals, Website: www.dcchemicals.com

Product Name: hVEGF-IN-1|Cas Number: 1637443-98-1| Catalog Number: DC10580

hVEGF-IN-1 represses human VEGF-A translation and shows antitumor activity.

hVEGF-IN-1 shows a significant specific interaction with the G-rich region within the 5′- untranslated regions (5′-UTR) of hVEGF-A mRNA and destabilizes the Gquadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM and binds to the hairpin DNA with a Kd of 21.2 μM. The G-rich sequence G774-G790 within the IRES-A of hVEGF-A’s 5′-UTR has been shown to be critical for the translation initiation activity of IRES-A. hVEGF-IN-1 hinders BG4 from binding to the IRES-A RNA G-quadruplex in cells. hVEGF-IN-1 down-regulates hVEGF-A’s translation via the G-quadruplex within IRES-A mRNA. hVEGF-IN-1 treatment reduces MDA-MB- 231 cell migration to approximately 25%.
Tumor bearing mice treated with hVEGF-IN-1 have an average tumor volume of less than 300 mm3. The tumor weight in the presence of hVEGF-IN-1 reduces around 60.1% to a final weight of 0.18 g. No significant change in body weight is observed during the treatment.

CAY 10602|cas 374922-43-7

CAY 10602|cas 374922-43-7

DC Chemicals, Website: www.dcchemicals.com

Product Name: CAY 10602|Cas Number: 374922-43-7| Catalog Number: DC10579

CAY10602 is a SIRT1 activator.

Compounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM.

rac BHFF|cas 123557-91-5

rac BHFF|cas 123557-91-5

DC Chemicals, Website: www.dcchemicals.com

Product Name: rac BHFF|Cas Number: 123557-91-5| Catalog Number: DC10578|Other Nmaes: racBHFF，rac-BHFF，rac BHFF

Rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the efficacy and potency of GABA ( > 149% and > 15-fold respectively). Orally active and exhibits anxiolytic activity in vivo.

Rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the efficacy and potency of GABA ( > 149% and > 15-fold respectively). Orally active and exhibits anxiolytic activity in vivo.

ADT-OH|cas 18274-81-2

ADT-OH|cas 18274-81-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: ADT-OH|Cas Number: 18274-81-2| Catalog Number: DC10577|Other Nmaes: ACS1

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor.

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. It can be readily esterified with other moieties.1 For example, it can be coupled with therapeutics like nonsteroidal anti-inflammatory drugs, as in the generation of ATB-3432 ADT-OH has also been linked with a mitochondria-targeting motif to produce AP-39 , which selectively increases mitochondrial H2S levels.ADT-OH is used both in cells and in animals for comparative studies with derived chimeras.

Cyantraniliprole|cas 736994-63-1

Cyantraniliprole|cas 736994-63-1

DC Chemicals, Website: www.dcchemicals.com

Product Name: Cyantraniliprole|Cas Number: 736994-63-1| Catalog Number: DC10576

Cyantraniliprole(HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.

Cyantraniliprole(HGW-86) is an insecticide of the ryanoid class; has activity against pests such as Diaphorina citri that have developed resistance to other classes insecticides.

Methyl 13-cis-4-Oxoretinoate|cas 71748-57-7

Methyl 13-cis-4-Oxoretinoate|cas 71748-57-7

DC Chemicals, Website: www.dcchemicals.com

Product Name: Methyl 13-cis-4-Oxoretinoate|Cas Number: 71748-57-7| Catalog Number: DC10575|Other Nmaes: Methyl 13-cis-4-Oxoretinoate; Methyl 13cis4Oxoretinoate; Methyl 13 cis 4 Oxoretinoate; 4-Keto-13-cis-Retinoic Acid Methyl ester; 4 Keto 13 cis Retinoic Acid Methyl ester

Methyl 13-cis-4-Oxoretinoate is a bioactive chemical.

CID-25014542|cas 220904-99-4

CID-25014542|cas 220904-99-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: CID-25014542|Cas Number: 220904-99-4| Catalog Number: DC10574|Other Nmaes: CID-25014542; CID25014542; CID 25014542

CID-25014542 is novel inhibitor of Raf kinases.

CID-25014542 is novel inhibitor of Raf kinases.

MDK34597 (PI3K inhibitor) |cas 371934-59-7

MDK34597 (PI3K inhibitor) |cas 371934-59-7

DC Chemicals, Website: www.dcchemicals.com

Product Name: MDK34597 (PI3K inhibitor) |Cas Number: 371934-59-7| Catalog Number: DC10573|Other Nmaes: MDK34597; MDK-34597; MDK 34597. PI3K inhibitor

MDK34597 is a PI3K inhibitor.MDK34597 is an analog of PI-103 and acts as a dual PI3K/mTOR Inhibitor.

MDK34597 is a PI3K inhibitor.MDK34597 is an analog of PI-103 and acts as a dual PI3K/mTOR Inhibitor.

MDK35833（Oct3/4-inducer-1）|cas 1016535-83-3

MDK35833（Oct3/4-inducer-1）|cas 1016535-83-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: MDK35833（Oct3/4-inducer-1）|Cas Number: 1016535-83-3| Catalog Number: DC10572|Other Nmaes: Oct3/4-inducer-1, MDK35833; MDK-35833; MDK 35833

MDK35833, also known as Oct3/4-inducer-1, is a potent Oct3/4-inducer.

MDK35833, also known as Oct3/4-inducer-1, is a potent Oct3/4-inducer. MDK35833 can promot expression and stabilization of Oct3/4 and enhance its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine.

MDK-8582（Hnps-PLA Inhibitor）|cas 185298-58-2

MDK-8582（Hnps-PLA Inhibitor）|cas 185298-58-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: MDK-8582（Hnps-PLA Inhibitor）|Cas Number: 185298-58-2| Catalog Number: DC10571|Other Nmaes: hnps-PLA Inhibitor; MDK-8582; MDK 8582; MDK8582

MDK-8582, also known as Hnps-PLA Inhibitor, is an nhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).

MDK-8582, also known as Hnps-PLA Inhibitor, is an nhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA). The best one inhibited hnps-PLA(2) and LTA(4)H-h with IC(50) values of 9.2 ± 0.5 μM and 2.4 ± 1.4 μM, respectively.

MDK74978（Multi-kinase inhibitor）|cas 778274-97-8

MDK74978（Multi-kinase inhibitor）|cas 778274-97-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: MDK74978（Multi-kinase inhibitor）|Cas Number: 778274-97-8| Catalog Number: DC10570|Other Nmaes: MDK74978; MDK-74978; MDK 74978. Multi-kinase inhibitor I

MDK74978, also known as Multi-kinase inhibitor I, is a Multi-kinase inhibitor. MDK74978 has CAS#778274-97-8. The last 5 digit was used in its name.

MDK1088（T.cruzi Inhibitor）|cas 1350920-22-7

MDK1088（T.cruzi Inhibitor）|cas 1350920-22-7

DC Chemicals, Website: www.dcchemicals.com

Product Name: MDK1088（T.cruzi Inhibitor）|Cas Number: 1350920-22-7| Catalog Number: DC10569|Other Nmaes: T.cruzi Inhibitor; MDK-1088; MDK1088; MDK 1088; MDK-1088 HCl; MDK-1088 hydrochloride

MDK-1088, also known as T.cruzi Inhibitor, is a Trypanosoma cruzi inhibitor. MDK-1088 has CAS#1350920-22-7 . The last 4 digit f CAS# was used in its name.

Mitapivat|PKM2 activator|cas 1260075-17-9

Mitapivat|PKM2 activator|cas 1260075-17-9

DC Chemicals, Website: www.dcchemicals.com

Product Name: Mitapivat|Cas Number: 1260075-17-9 | Catalog Number: DC10568|Other Nmaes: Mitapivat,PKM2 activator,cas 1260075-17-9

Mitapivat  is an activator of pyruvate kinase isoenzyme M2 (PKM2)

Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases.

KKL-10|KKL10|cas 952849-76-2|ribosome rescue inhibitor

KKL-10|KKL10|cas 952849-76-2|ribosome rescue inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: KKL-10|Cas Number: 952849-76-2| Catalog Number: DC10567|Other Nmaes: KKL-10,KKL 10,KKL10

KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.

The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.

PF6260933|PF-6260933|MAP4K4 inhibitor|cas 1811510-56-1

PF6260933|PF-6260933|MAP4K4 inhibitor|cas 1811510-56-1

DC Chemicals, Website: www.dcchemicals.com

Product Name: PF6260933|Cas Number: 1811510-56-1| Catalog Number: DC10566|Other Nmaes: PF6260933,PF-6260933,PF 6260933

PF6260933 is a novel MAP4K4 inhibitor.

PX-102(PX-20606)|cas 1268244-85-4

PX-102(PX-20606)|cas 1268244-85-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: PX-102(PX-20606)|Cas Number: 1268244-85-4| Catalog Number: DC10565|Other Nmaes: PX102,PX20606,PX 102,PX 20606,PX-102,PX-20606

PX20606, also known as PX-102, is a FXR agonist.

BAR 502

BAR 502

DC Chemicals, Website: www.dcchemicals.com

Product Name: BAR 502|Cas Number: 1612191-86-2| Catalog Number: DC10564|Other Nmaes: BAR 502,BAR-502,BAR502

BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.

E-7046|cas 1369489-71-3

E-7046|cas 1369489-71-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: E-7046 |Cas Number: 1369489-71-3| Catalog Number: DC10563|Other Nmaes: E-7046,E 7046,E7046

E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities.

MTX-211|cas 1952236-05-3

MTX-211|cas 1952236-05-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: MTX-211 |Cas Number: 1952236-05-3| Catalog Number: DC10562|Other Nmaes: MTX-211,MTX 211 ,MTX211

MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases.

GSK-2018682 |cas 1034688-30-6

GSK-2018682 |cas 1034688-30-6

DC Chemicals, Website: www.dcchemicals.com

Product Name: GSK-2018682 |Cas Number: 1034688-30-6| Catalog Number: DC10561|Other Nmaes: GSK-2018682 ,GSK 2018682 ,GSK2018682

GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis.

MAK683|MAK-683|EED/PRC2 inhibitor|cas 1951408-58-4

MAK683|MAK-683|EED/PRC2 inhibitor|cas 1951408-58-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: MAK683|Cas Number: 1951408-58-4| Catalog Number: DC10560|Other Nmaes: MAK 683,MAK-683,MAK683

MAK683 is a novel PRC2/EED inhibitor.

Derazantinib (ARQ 087)|cas 1234356-69-4

Derazantinib (ARQ 087)|cas 1234356-69-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: Derazantinib (ARQ 087)|Cas Number: 1234356-69-4| Catalog Number: DC10559|Other Nmaes: ARQ-087,ARQ087,Derazantinib,ARQ 087

Derazantinib (Derazantinib) is an ATP competitive tyrosine kinase inhibitor; exhibits potent activity against FGFR1-3 chondrocytes with IC50s of 4.5, 1.8, and 4.5 nM, respectively.

ASP 7663|TRPA1 activator|ASP7663|1190217-35-6

ASP 7663|TRPA1 activator|ASP7663|1190217-35-6

DC Chemicals, Website: www.dcchemicals.com

Product Name: ASP 7663|Cas Number: 1190217-35-6| Catalog Number: DC10558|Other Nmaes: ASP 7663,ASP-7663,ASP7663

ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat).

ML402|ML402|cas 298684-44-3|TREK-1 activator

ML402|ML402|cas 298684-44-3|TREK-1 activator

DC Chemicals, Website: www.dcchemicals.com

Product Name: ML402 |Cas Number: 298684-44-3| Catalog Number: DC10557|Other Nmaes: ML402,ML-402 ,ML 402

ML402 is a selective TREK-1 activator.

KY1220|KY-1220|TREK-1 activator|cas 292168-79-7

KY1220|KY-1220|TREK-1 activator|cas 292168-79-7

DC Chemicals, Website: www.dcchemicals.com

Product Name: KY1220 |Cas Number: 292168-79-7| Catalog Number: DC10556|Other Nmaes: KY 1220,KY-1220,KY1220

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

inS3-54A18|STAT3 inhibitor|cas 328998-53-4

inS3-54A18|STAT3 inhibitor|cas 328998-53-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: inS3-54A18 |Cas Number: 328998-53-4| Catalog Number: DC10555

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.

DC260126|antagonist of GPR40|cas 346692-04-4

DC260126|antagonist of GPR40|cas 346692-04-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: DC260126 |Cas Number: 346692-04-4| Catalog Number: DC10554|Other Nmaes: DC260126,DC-260126 ,DC 260126

DC260126, a small-molecule antagonist of GPR40.

ST034307|ST-034307|AC1 inhibitor|cas 133406-29-8

ST034307|ST-034307|AC1 inhibitor|cas 133406-29-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: ST034307|Cas Number: 133406-29-8| Catalog Number: DC10553|Other Nmaes: ST034307,ST-034307,ST 034307

ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.

KKL-10|KKL10|cas 952849-76-2|ribosome rescue inhibitor

KKL-10|KKL10|cas 952849-76-2|ribosome rescue inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: KKL-10|Cas Number: 952849-76-2| Catalog Number: DC10567|Other Nmaes: KKL-10,KKL 10,KKL10

KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.

The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.

PF6260933|PF-6260933|MAP4K4 inhibitor|cas 1811510-56-1

PF6260933|PF-6260933|MAP4K4 inhibitor|cas 1811510-56-1

DC Chemicals, Website: www.dcchemicals.com

Product Name: PF6260933|Cas Number: 1811510-56-1| Catalog Number: DC10566|Other Nmaes: PF6260933,PF-6260933,PF 6260933

PF6260933 is a novel MAP4K4 inhibitor.

PX-102(PX-20606)|cas 1268244-85-4

PX-102(PX-20606)|cas 1268244-85-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: PX-102(PX-20606)|Cas Number: 1268244-85-4| Catalog Number: DC10565|Other Nmaes: PX102,PX20606,PX 102,PX 20606,PX-102,PX-20606

PX20606, also known as PX-102, is a FXR agonist.

BAR 502

BAR 502

DC Chemicals, Website: www.dcchemicals.com

Product Name: BAR 502|Cas Number: 1612191-86-2| Catalog Number: DC10564|Other Nmaes: BAR 502,BAR-502,BAR502

BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.

E-7046|cas 1369489-71-3

E-7046|cas 1369489-71-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: E-7046 |Cas Number: 1369489-71-3| Catalog Number: DC10563|Other Nmaes: E-7046,E 7046,E7046

E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities.

MTX-211|cas 1952236-05-3

MTX-211|cas 1952236-05-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: MTX-211 |Cas Number: 1952236-05-3| Catalog Number: DC10562|Other Nmaes: MTX-211,MTX 211 ,MTX211

MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases.

GSK-2018682 |cas 1034688-30-6

GSK-2018682 |cas 1034688-30-6

DC Chemicals, Website: www.dcchemicals.com

Product Name: GSK-2018682 |Cas Number: 1034688-30-6| Catalog Number: DC10561|Other Nmaes: GSK-2018682 ,GSK 2018682 ,GSK2018682

GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis.

MAK683|MAK-683|EED/PRC2 inhibitor|cas 1951408-58-4

MAK683|MAK-683|EED/PRC2 inhibitor|cas 1951408-58-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: MAK683|Cas Number: 1951408-58-4| Catalog Number: DC10560|Other Nmaes: MAK 683,MAK-683,MAK683

MAK683 is a novel PRC2/EED inhibitor.

Derazantinib (ARQ 087)|cas 1234356-69-4

Derazantinib (ARQ 087)|cas 1234356-69-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: Derazantinib (ARQ 087)|Cas Number: 1234356-69-4| Catalog Number: DC10559|Other Nmaes: ARQ-087,ARQ087,Derazantinib,ARQ 087

Derazantinib (Derazantinib) is an ATP competitive tyrosine kinase inhibitor; exhibits potent activity against FGFR1-3 chondrocytes with IC50s of 4.5, 1.8, and 4.5 nM, respectively.

ASP 7663|TRPA1 activator|ASP7663|1190217-35-6

ASP 7663|TRPA1 activator|ASP7663|1190217-35-6

DC Chemicals, Website: www.dcchemicals.com

Product Name: ASP 7663|Cas Number: 1190217-35-6| Catalog Number: DC10558|Other Nmaes: ASP 7663,ASP-7663,ASP7663

ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat).

ML402|ML402|cas 298684-44-3|TREK-1 activator

ML402|ML402|cas 298684-44-3|TREK-1 activator

DC Chemicals, Website: www.dcchemicals.com

Product Name: ML402 |Cas Number: 298684-44-3| Catalog Number: DC10557|Other Nmaes: ML402,ML-402 ,ML 402

ML402 is a selective TREK-1 activator.

KY1220|KY-1220|TREK-1 activator|cas 292168-79-7

KY1220|KY-1220|TREK-1 activator|cas 292168-79-7

DC Chemicals, Website: www.dcchemicals.com

Product Name: KY1220 |Cas Number: 292168-79-7| Catalog Number: DC10556|Other Nmaes: KY 1220,KY-1220,KY1220

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

inS3-54A18|STAT3 inhibitor|cas 328998-53-4

inS3-54A18|STAT3 inhibitor|cas 328998-53-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: inS3-54A18 |Cas Number: 328998-53-4| Catalog Number: DC10555

inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.

DC260126|antagonist of GPR40|cas 346692-04-4

DC260126|antagonist of GPR40|cas 346692-04-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: DC260126 |Cas Number: 346692-04-4| Catalog Number: DC10554|Other Nmaes: DC260126,DC-260126 ,DC 260126

DC260126, a small-molecule antagonist of GPR40.

ST034307|ST-034307|AC1 inhibitor|cas 133406-29-8

ST034307|ST-034307|AC1 inhibitor|cas 133406-29-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: ST034307|Cas Number: 133406-29-8| Catalog Number: DC10553|Other Nmaes: ST034307,ST-034307,ST 034307

ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.

ST034307|ST-034307|AC1 inhibitor|cas 133406-29-8

ST034307|ST-034307|AC1 inhibitor|cas 133406-29-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: ST034307|Cas Number: 133406-29-8| Catalog Number: DC10553|Other Nmaes: ST034307,ST-034307,ST 034307

ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.

AU1235|AU-1235|cas 1338780-86-1

AU1235|AU-1235|cas 1338780-86-1

DC Chemicals, Website: www.dcchemicals.com

Product Name: AU1235|Cas Number: 1338780-86-1| Catalog Number: DC10552|Other Nmaes: AU1235,AU-1235,AU 1235

AU1235 is an adamantyl urea inhibitor of Mycobacterium tuberculosis.

Necrostatin 2 racemate|cas 852391-15-2

Necrostatin 2 racemate|cas 852391-15-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: Necrostatin 2 racemate|Cas Number: 852391-15-2| Catalog Number: DC10551

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

DKM 2-93|inhibitor of UBA5|cas 65836-72-8

DKM 2-93|inhibitor of UBA5|cas 65836-72-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: DKM 2-93 |Cas Number: 65836-72-8| Catalog Number: DC10550|Other Nmaes: DKM 2-93

DKM 2-93 is a relatively selective inhibitor of UBA5 with an IC50 of 430 μM.

Nomifensine maleate|cas 32795-47-4

Nomifensine maleate|cas 32795-47-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: Nomifensine maleate|Cas Number: 32795-47-4| Catalog Number: DC10549

Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.

Auten-99|MTMR14 inhibitor|cas 1049780-58-6

Auten-99|MTMR14 inhibitor|cas 1049780-58-6

DC Chemicals, Website: www.dcchemicals.com

Product Name: Auten-99|Cas Number: 1049780-58-6| Catalog Number: DC10548|Other Nmaes: Auten-99,Auten 99,Auten99

Auten-99 is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14), acrossing the blood-brain barrier and exerting potent neuroprotective effects.

Ensartinib|cas 1365267-27-1|ALK inhibitor

Ensartinib|cas 1365267-27-1|ALK inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: Ensartinib|Cas Number: 1365267-27-1| Catalog Number: DC10547

Ensartinib is a potent inhibitor of ALK, which is used to treat non-small-cell lung cancer.

GNE-495|GNE495|MAP4K4 inhibitor|cas 1449277-10-4

GNE-495|GNE495|MAP4K4 inhibitor|cas 1449277-10-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: GNE-495|Cas Number: 1449277-10-4| Catalog Number: DC10546|Other Nmaes: GNE-495,GNE 495,GNE495

GNE-495 is a potent and Selective MAP4K4 Inhibitor with IC50 of 3.7 nM.

AX-024|AX024|TCR inhibitor|cas 1704801-24-0

AX-024|AX024|TCR inhibitor|cas 1704801-24-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: AX-024|Cas Number: 1704801-24-0| Catalog Number: DC10545|Other Nmaes: AX-024,AX024,AX 024

AX-024 is the first-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM).

AX-024 is the first-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). By modulating TCR signaling, the inhibitor prevented the development of psoriasis and asthma and, furthermore, exerted a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis.

MKC3946|MKC-3946|IRE1α inhibitor|cas 1093119-54-0

MKC3946|MKC-3946|IRE1α inhibitor|cas 1093119-54-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: MKC3946|Cas Number: 1093119-54-0| Catalog Number: DC10544|Other Nmaes: MKC3946,MKC-3946,MKC 3946

MKC3946 is a potent and soluble IRE1α inhibitor, used for cancer research.

MKC-3946 blocks XBP1 mRNA splicing and exhibits cytotoxicity against AML cells. MKC-3946 inhibits XBP1S expression induced by tunicamycin (TM) in NB4 cells (B) and AML sample from patients. MKC-3946 prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production. MKC-3946 is an IRE1α endoribonuclease domain inhibitor that blocks XBP1 mRNA splicing and triggers modest growth inhibition in MM cells. MKC-3946 inhibits XBP1s expression induced by Tm in a dose-dependent manner, but does not affect phosphorylation of IRE1α. MKC-3946 blocks XBP1 splicing and enhances cytotoxicity induced by bortezomib or 17-AAG. MKC-3946 (10μM) enhances ER stress-mediated apoptosis induced by bortezomib or 17-AAG, and enhances cytotoxicity of ER stressors, even in the presence of BMSCs or exogenous IL-6.MKC-3946 (100 mg/kg, i.p.) inhibits XBP1 splicing in a model of ER stress in vivo, associated with significant growth inhibition of MM cells, alone or with bortezomib. MKC-3946 significantly reduces MM tumor growth in the treatment versus control group. Inhibition of XBP1 splicing by MKC-3946 is associated with decreased MM growth in vivo, alone or in combination with bortezomib.

KIRA6|cas 1589527-65-0|IRE1 Inhibitor 6

KIRA6|cas 1589527-65-0|IRE1 Inhibitor 6

DC Chemicals, Website: www.dcchemicals.com

Product Name: KIRA6|Cas Number: 1589527-65-0| Catalog Number: DC10542|Other Nmaes: KIRA6,IRE1 Inhibitor IV,IRE1α Kinase Inhibiting RNase Attenuator 6

KIRA6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 µM) and prevents oligomerization.

The IRE1 pathway is a component of the unfolded protein response that senses unfolded proteins via an ER luminal domain that becomes oligomerized during stress. It is associated with promoting cell survival through the activity of the IRE1α RNase, whose activity upregulates proteins that enhance ER protein folding and quality control. However, under high ER stress, the IRE1α RNase becomes hyperactive and is less discriminant in its substrate specificity, endonucleolytically cleaving many additional mRNAs that localize to the ER membrane, leading to cell proliferation blocks, inflammation, and apoptosis. KIRA6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 µM) and prevents oligomerization.1 It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.At 20 µg/ml, KIRA6 is reported to preserve photoreceptor functional viability in rat models of ER stress-induced retinal degeneration.1 At 5 mg/kg, it has also been shown to preserve pancreatic β cells, increase insulin, and reduce hyperglycemia in Akita diabetic mice.

Cyclo(RGDfC)|integrin avb3-affine peptide

Cyclo(RGDfC)|integrin avb3-affine peptide

DC Chemicals, Website: www.dcchemicals.com

Product Name: Cyclo(RGDfC)|Cas Number: N/A| Catalog Number: DC10541|Other Nmaes: Cyclo(Arg-Gly-Asp-D-Phe-Cys)，RGDfC

Cyclo (RGDfC), avb3 Integrin Binding Cyclic RGD Peptide,This is a cyclic RGDfC sequence, an integrin avb3-affine peptide.

NVP-BQR695|BQR 695|PI3K inhibitor|cas 1513879-21-4

NVP-BQR695|BQR 695|PI3K inhibitor|cas 1513879-21-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: NVP-BQR695|Cas Number: 1513879-21-4| Catalog Number: DC10540|Other Nmaes: NVP-BQR-695，NVP-BQR 695，NVP-BQR695

NVP-BQR695 is a novel PI3K inhibitor.

CAS 1822358-25-7|DC Chemicals

CAS 1822358-25-7|DC Chemicals

DC Chemicals, Website: www.dcchemicals.com

Cas Number: 1822358-25-7| Catalog Number: DC10539

IDH-305|IDH305|IDH1(R132) inhibitor

IDH-305|IDH305|IDH1(R132) inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: IDH-305|Cas Number: 1628805-46-8| Catalog Number: DC10538|Other Nmaes: IDH-305,IDH 305,IDH305

IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity.

IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity. Upon administration, IDH305 specifically inhibits IDH1(R132) mutant forms in the cytoplasm, which inhibits the formation of the oncometabolite 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1(R132)-expressing tumor cells.

8-OH-DPAT|cas 78950-78-4

8-OH-DPAT|cas 78950-78-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: 8-OH-DPAT|Cas Number: 78950-78-4| Catalog Number: DC10537

8-OH-DPAT is a research chemical of the aminotetralin chemical class and has been widely used to study the function of the 5-HT1A receptor.

KML-29|KML29|cas 1380424-42-9

KML-29|KML29|cas 1380424-42-9

DC Chemicals, Website: www.dcchemicals.com

Product Name: KML-29|Cas Number: 1380424-42-9| Catalog Number: DC10536|Other Nmaes: KML29,KML-29,KML 29

KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM).

KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). At 5-20 mg/kg, KML29 dose-dependently blocks mouse brain MAGL activity in vivo, without any measurable effect on FAAH activity.As a second generation MAGL inhibitor, KML29 supersedes the low-level cross reactivity that JZL 184 displays for FAAH yet still maintains comparable potency to its parent compound..

CCG-203971|CCG-203971|cas 1443437-74-8

CCG-203971|CCG-203971|cas 1443437-74-8

DC Chemicals, Website: www.dcchemicals.com

Product Name: CCG-203971|Cas Number: 1443437-74-8| Catalog Number: DC10535|Other Nmaes: CCG 203971,CCG203971,CCG-203971

CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50 = 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.

CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50 = 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.2 This compound also inhibits PC-3 cell migration (IC50 = 4.2 μM), as determined by a scratch wound assay. CCG-203971 causes no cytotoxicity when evaluated by WST-1 assay.2 It is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days.

AZD0865|Linaprazan|AZD-0865|cas 847574-05-4

AZD0865|Linaprazan|AZD-0865|cas 847574-05-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: AZD0865(Linaprazan)|Cas Number: 847574-05-4| Catalog Number: DC10534|Other Nmaes: AZD0865，AZD-0865，AZD 0865

AZD0865 is a potent agent that inhibits gastric H(+),K(+)-ATPase activity and acid formation in vitro, with a fast onset of effect.

AZD0865 is a member of a drug class that inhibits gastric H(+),K(+)-ATPase by K(+)-competitive binding. The objective of these experiments was to characterize the mechanism of action, selectivity and inhibitory potency of AZD0865 in vitro. In porcine ion-leaky vesicles at pH 7.4, AZD0865 concentration-dependently inhibited K(+)-stimulated H(+),K(+)-ATPase activity (IC(50) 1.0+/-0.2 microM) but was more potent at pH 6.4 (IC(50) 0.13+/-0.01 microM). The IC(50) values for a permanent cation analogue, AR-H070091, were 11+/-1.2 microM at pH 7.4 and 16+/-1.8 microM at pH 6.4. These results suggest that the protonated form of AZD0865 inhibits H(+),K(+)-ATPase. In ion-tight vesicles, AZD0865 inhibited H(+),K(+)-ATPase more potently (IC(50) 6.9+/-0.4 nM) than in ion-leaky vesicles, suggesting a luminal site of action. AZD0865 inhibited acid formation in histamine- or dibutyryl-cAMP-stimulated rabbit gastric glands (IC(50) 0.28+/-0.01 and 0.26+/-0.003 microM, respectively). In ion-leaky vesicles at pH 7.4, AZD0865 (3 microM) immediately inhibited H(+),K(+)-ATPase activity by 88+/-1%. Immediately after a 10-fold dilution H(+),K(+)-ATPase inhibition was 41%, indicating reversible binding of AZD0865 to gastric H(+),K(+)-ATPase. In contrast to omeprazole, AZD0865 inhibited H(+),K(+)-ATPase activity in a K(+)-competitive manner (K(i) 46+/-3 nM). AZD0865 inhibited the process of cation occlusion concentration-dependently (IC(50) 1.7+/-0.06 microM). At 100 microM, AZD0865 reduced porcine renal Na(+),K(+)-ATPase activity by 9+/-2%, demonstrating a high selectivity for H(+),K(+)-ATPase. Thus, AZD0865 potently, K(+)-competitively, and selectively inhibits gastric H(+),K(+)-ATPase activity and acid formation in vitro, with a fast onset of effect.

PKM2 inhibitor|cas 94164-88-2

PKM2 inhibitor|cas 94164-88-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: PKM2 inhibitor|Cas Number: 94164-88-2| Catalog Number: DC10533

A novle PKM2 inhibitor  inhibitor.

Mirogabalin (DS-5565)| α2δ-1 ligand|cas|1138245-13-2

Mirogabalin (DS-5565)| α2δ-1 ligand|cas|1138245-13-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: Mirogabalin besylate|Cas Number: 1138245-21-2| Catalog Number: DC10532|Other Nmaes: DS 5565,DS-5565,DS5565

Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS.

Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS.
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the central nervous system (CNS). In vitro experiments using membrane preparations from human and rat α2δ subunit-expressed cells show that Mirogabalin had a slower dissociation rate from α2δ-1 than α2δ-2, in particular, α2δ-1 compared with Pregabalin. Additionally, Mirogabalin shows potent, sustained analgesic effects in streptozotocin-induced diabetic rats with induces pain, and the superior analgesic effects and wider CNS safety margin relative to Pregabalin are attributed to its selectivity for and slow dissociation from α2δ-1 compared with Pregabalin[1]. Mirogabalin (DS-5565) is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia. Mirogabalin targets α2δ-1, an auxiliary protein associated with voltage-sensitive calcium channel complexes in the central nervous system. This binding reduces calcium influx at nerve terminals, therefore reducing the release of several pain neurotransmitters. The ED50 (on the transformed scale) for Mirogabalin is estimated to be 20.5 mg with a 90% confidence interval (CI) of 10.1-41.7 mg.
InVivo: Additionally, Mirogabalin shows potent, sustained analgesic effects in streptozotocin-induced diabetic rats with induced pain, and the superior analgesic effects and wider central nervous system (CNS) safety margin relative to Pregabalin are attributed to its selectivity for and slow dissociation from α2δ-1 compared with Pregabalin.

PCO371|PCO-371|1613373-33-3|agonist of PTHR1

PCO371|PCO-371|1613373-33-3|agonist of PTHR1

DC Chemicals, Website: www.dcchemicals.com

Product Name: PCO371|Cas Number: 1613373-33-3| Catalog Number: DC10531|Other Nmaes: PCO 371,PCO371,PCO-371

PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1.

PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation. Oral administration of PCO371 to osteopenic rats provokes a significant increase in bone turnover with limited increase in bone mass. In hypocalcemic rats, PCO371 restores serum calcium levels without increasing urinary calcium, and with stronger and longer-lasting effects than PTH injections. These results strongly suggest that PCO371 can provide a new treatment option for PTH-related disorders, including hypoparathyroidism.

BLU-285 (Avapritinib)|exon 17 mutant KIT inhibitor

BLU-285 (Avapritinib)|exon 17 mutant KIT inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: BLU-285 (Avapritinib)|Cas Number: 1703793-34-3| Catalog Number: DC10530|Other Nmaes: BLU-285,BLU 285,BLU285

BLU-285 is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V.

BLU-285 has demonstrated biochemical in vitro activity on the KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Cellular activity of BLU-285 on KIT D816 mutants is measured by autophosphorylation in the human mast cell leukemia cell line HMC1.2, and the P815 mouse mastocytoma cell line with IC50=4 and 22 nM, respectively. In Kasumi-1 cells, a t(8;21)-positive AML cell line with a KIT exon 17 N822K mutation, BLU-285 potently inhibits KIT N822K mutant autophosphorylation (IC50=40 nM), downstream signaling, as well as cellular proliferation (IC50=75 nM).

PF-05089771,PF05089771|Nav1.7 channel blocker

PF-05089771,PF05089771|Nav1.7 channel blocker

DC Chemicals, Website: www.dcchemicals.com

Product Name: PF 05089771|Cas Number: 1235403-62-9| Catalog Number: DC10529|Other Nmaes: PF 05089771,PF-05089771,PF05089771

PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.

PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.

CP 376395|CP376395|CRF1 receptor antagonist

CP 376395|CP376395|CRF1 receptor antagonist

DC Chemicals, Website: www.dcchemicals.com

Product Name: CP 376395|Cas Number: 175140-00-8| Catalog Number: DC10528|Other Nmaes: CP376395,CP-376395,CP 376395

CP 376395 is a potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively).

CP 376395 is a potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively).

CPI-444|CPI444|adenosine A2A receptor antagonist

CPI-444|CPI444|adenosine A2A receptor antagonist

DC Chemicals, Website: www.dcchemicals.com

Product Name: CPI-444|Cas Number: 1202402-40-1| Catalog Number: DC10527|Other Nmaes: CPI-444,CPI 444,CPI444

CPI-444 is an orally administered antagonist of the adenosine A2A receptor. It is designed to block the action of adenosine that is produced by tumors.

CPI-444 is an orally administered antagonist of the adenosine A2A receptor. It is designed to block the action of adenosine that is produced by tumors. CPI-444 blocks adenosine from binding to the A2A receptor. Adenosine suppresses the anti-tumor activity of T cells and other immune cells.

BAY-1895344|BAY1895344|cas 1876467-74-1|ATM inhibitor

BAY-1895344|BAY1895344|cas 1876467-74-1|ATM inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: BAY-1895344|Cas Number: 1876467-74-1| Catalog Number: DC10526|Other Nmaes: BAY1895344,BAY 1895344,BAY-1895344

BAY-1895344 is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.

BAY-1895344 is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.

AKP-11|AKP11|cas 1220973-37-4|S1P1 Agonist

AKP-11|AKP11|cas 1220973-37-4|S1P1 Agonist

DC Chemicals, Website: www.dcchemicals.com

Product Name: AKP-11|Cas Number: 1220973-37-4| Catalog Number: DC10525|Other Nmaes: AKP-11,AKP 11,AKP11

AKP-11 is A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis.

AKP-11 is A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis.Like FTY720, AKP-11 bound to S1P1 is internalized and activates intracellular AKT and ERKs cellular signaling pathways. In contrast to FTY720, AKP-11 mediated S1P1 downregulation is independent of sphingosine kinase activity indicating it to be a direct agonist of S1P1. The S1P1 loss and inhibition of lymphocyte egress by FTY720 leads to lymphopenia. In comparison with FTY720, oral administration of AKP-11 caused milder and reversible lymphopenia while providing a similar degree of therapeutic efficacy in the EAE animal model. Consistent with the observed reversible lymphopenia with AKP-11, the S1P1 recycled back to cell membrane in AKP-11 treated cells following its withdrawal, but not with withdrawal of FTY720. Accordingly, a smaller degree of ubiquitination and proteolysis of S1P1 was observed in AKP-11 treated cells as compared to FTY720.

Monastrol|Eg5 inhibitor|cas 254753-54-3

Monastrol|Eg5 inhibitor|cas 254753-54-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: Monastrol|Cas Number: 254753-54-3| Catalog Number: DC10524

Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).

TAK-659|TAK-659|Syk inhibitor

TAK-659|TAK-659|Syk inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: TAK-659|Cas Number: 1952251-28-3| Catalog Number: DC10523|Other Nmaes: TAK659,TAK 659,TAK-659

TAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM.

TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.

FIN56|FIN56

FIN56|FIN56

DC Chemicals, Website: www.dcchemicals.com

Product Name: FIN56|Cas Number: 1083162-61-1| Catalog Number: DC10522|Other Nmaes: FIN56,FIN-56 ,FIN 56

FIN56 is a specific inducer of ferroptosis.

FIN56 causes the loss of GPX4 activity in cell lysates. FIN56-induced cell death is suppressed by GFP-GPX4 fusion protein overexpression. FIN56 triggers ferroptosis through a mechanism involving the regulation of GPX4 protein abundance[1].

(R)-IMPP|PCSK9 inhibitor

(R)-IMPP|PCSK9 inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: (R)-IMPP|Cas Number: N/A| Catalog Number: DC10521|Other Nmaes: R-IMPP

(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 µM).

(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 µM).

E6446 dihydrochlorid|E-6446|CAS 1345675-25-3

E6446 dihydrochlorid|E-6446|CAS 1345675-25-3

DC Chemicals, Website: www.dcchemicals.com

Product Name: E6446 dihydrochloride|Cas Number: 1345675-25-3 | Catalog Number: DC10520|Other Nmaes: E6446,E 6446,E-6446

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM. IC50 value: 10 nM(HEK:TLR9 cell) [1] Target: TLRs inhibitor in vitro: E6446 potently inhibited IL-6 production induced by CpG2216 but was ineffective against induction by the TLR3 ligand poly inosine-cytosine. E6446 showed a modest but consistent superiority over AT791, and both were significantly more potent than hydroxychloroquine. Significantly, 250 nM and 1.25 μM E6446 completely suppressed all of the CpG oligo-induced changes in gene expression [1]. E6446 specifically inhibited TLR9 activation with CpG ODN 2006, in the range of 0.01–0.03 μM. A 100-fold higher concentration (2–8 μM) of E6446 was required to inhibit TLR7/8 activated by the imidazoquinoline compound R848 [2]. in vivo: To test their activity in vivo, mice were orally dosed with 20 mg/kg of AT791 or E6446 and 18 hours later were challenged with 60 μg CpG1668 oligonucleotide injected subcutaneously. CpG1668-induced IL-6 production was inhibited ~50% by AT791 and almost completely by E6446 [1]. therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection

SU 5214|SU5214|cas 186611-04-1

SU 5214|SU5214|cas 186611-04-1

DC Chemicals, Website: www.dcchemicals.com

Product Name: SU 5214|Cas Number: 186611-04-1 | Catalog Number: DC10519|Other Nmaes: SU 5214,SU-5214,SU5214

SU 5214 is a modulator of tyrosine kinase signal transduction.

KIN1148|KIN-1148|cas 1428729-56-9|IRF3 agonist

KIN1148|KIN-1148|cas 1428729-56-9|IRF3 agonist

DC Chemicals, Website: www.dcchemicals.com

Product Name: KIN1148|Cas Number: 1428729-56-9| Catalog Number: DC10518|Other Nmaes: KIN1148,KIN-1148,KIN 1148

KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy.

KIN1148 induces the dose-dependent nuclear translocation of IRF3 in PH5CH8 cells and specific activation of IRF3- responsive promoters. KIN1148 also elicits greater induction of endogenous IRF3-dependent ISG54 and OASL expression by PH5CH8 cells.

HMN-154，HMN154|cas 173528-92-2

HMN-154，HMN154|cas 173528-92-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: HMN-154|Cas Number: 173528-92-2| Catalog Number: DC10517|Other Nmaes: HMN-154，HMN 154，HMN154

HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.

HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.

CAY10585|LW6|CAS 934593-90-5|HIF-1 inhibitor

CAY10585|LW6|CAS 934593-90-5|HIF-1 inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: CAY10585|Cas Number: 934593-90-5| Catalog Number: DC10516|Other Nmaes: CAY 10585,CAY-10585,CAY10585,LW6

CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM, respectively.

CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM, respectively. It blocks HIF-1α accumulation in Hep3B cells in a concentration and time-dependent manner, with complete inhibition at a concentration of 30 µM within 12 hours. CAY10585 also significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin at 10 µM.

BQCA|cas 338747-41-4

BQCA|cas 338747-41-4

DC Chemicals, Website: www.dcchemicals.com

Product Name: BQCA|Cas Number: 338747-41-4 | Catalog Number: DC10515

BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5.

BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5. Stimulation of the cortical muscarinic M1 receptor (CHRM1) is proposed as a treatment for schizophrenia, a hypothesis testable using CHRM1 allosteric modulators. BQCA binds allosterically to M1 to enhance the binding and efficacy of ACh at the receptor. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s.

SMI-16a|SMI16a|cas 587852-28-6|Pim kinase inhibitor

SMI-16a|SMI16a|cas 587852-28-6|Pim kinase inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: SMI-16a|Cas Number: 587852-28-6| Catalog Number: DC10514|Other Nmaes: SMI-16a,SMI 16a,SMI16a

SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.SMI-16a has excellent potency for inhibition of both Pim-1 and Pim-2. Treatment with Pim-2 short-interference RNA as well as the Pim inhibitor SMI-16a successfully restores osteoblastogenesis suppressed by all the above inhibitory factors and MM cells. The SMI-16a treatment potentiates BMP-2-mediated anabolic signaling while suppressing TGF-β signaling.Mice tolerate intraperitoneal dose of SMI-16a is 50 mg/kg daily for 5 days, while 100 mg/kg is overtly toxic. Treatment of the animals with SMI-16a for 5 days per week reduces the growth of tumors by approximately 50% and does not cause a loss of body weight. Subchronic dosing with SMI-16a does not affect the levels of red, white blood cells, including lymphocytes, monocytes, and granulocytes, indicating that the compound does not have myelosuppressive effects. SMI-16a does not have toxicity toward the liver as the albumin, alkaline phosphatase, and alanine aminotransferase levels are unchanged. SMI-16a effectively prevents bone destruction while suppressing MM tumor growth in MM animal models.

AFN-1252(Debio 1452)|cas 620175-39-5|FabI inhibitor

AFN-1252(Debio 1452)|cas 620175-39-5|FabI inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: AFN-1252(Debio 1452)|Cas Number: 620175-39-5| Catalog Number: DC10513|Other Nmaes: API1252; Debio1452,API 1252; Debio-1452,API1252; Debio1452

AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml.

Sarecycline（P005672）|cas 1035979-44-2

Sarecycline（P005672）|cas 1035979-44-2

DC Chemicals, Website: www.dcchemicals.com

Product Name: Sarecycline（P005672）|Cas Number: 1035979-44-2| Catalog Number: DC10512|Other Nmaes: Sarecycline（P005672），P-005672，P 005672

Sarecycline（P005672） is a novel, tetracycline-derived, narrow-spectrum antibiotic being developed for use as an oral once daily antibiotic treatment for patients suffering from moderate to severe acne vulgaris.

Sarecycline, also known as P005672, is a novel, tetracycline-derived, narrow-spectrum antibiotic being developed for use as an oral once daily antibiotic treatment for patients suffering from moderate to severe acne vulgaris. Sarecycline was designed by Paratek as a narrow-spectrum antibiotic with anti-inflammatory activity and the potential for a favorable tolerability profile.

SBI-0640756（SBI-756）|eIF4G1 inhibitor

SBI-0640756（SBI-756）|eIF4G1 inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: SBI-0640756（SBI-756）|Cas Number: N/A| Catalog Number: DC10511|Other Nmaes: SBI-0640756,SBI 0640756,SBI0640756,SBI 756,SBI756,SBI-756

SBI-0640756（SBI-756） is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.

SBI-0640756（SBI-756） is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. SBI-756 also suppressed AKT and NF-κB signaling. 1) SBI-756 inhibited the growth of NRAS, BRAF, and NF1-mutant melanomas . 2) SBI-756 attenuates resistance to BRAFi and inhibits NRAS- and NF1-mutant melanomas. 3) SBI-756 delayed the onset and reduced the incidence of Nras/Ink4a melanomas

FPH1(BRD-6125)|CAS 708219-39-0

FPH1(BRD-6125)|CAS 708219-39-0

DC Chemicals, Website: www.dcchemicals.com

Product Name: FPH1 (BRD-6125)|Cas Number: 708219-39-0| Catalog Number: DC10510|Other Nmaes: FPH1,BRD-6125,BRD 6125,BRD6125

FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes.

A196|A-196|H4K20me inhibitor

A196|A-196|H4K20me inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: A-196|Cas Number: N/A| Catalog Number: DC10509|Other Nmaes: A-196,A 196,A196

A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines.

A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. Target: A-196 is a selective chemical probe for SUV420H1/H2. A-196 is the first potent and selective chemical probe for SUV420H1 and SUV420H2. The in vitro activity of A-196 includes inhibition of SUV420H1 with IC50 = 25 nM and SUV420H2 with IC50 = 144 nM for methylation of H4K20me and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In cell assays, A-196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines with IC50 < 1 μM. SUV420H1 and SUV420H2 are two highly homologous methyltransferases that di- and tri-methylate 'Lys-20' of histone H4.

LYS05|LYS-05|lysosomal autophagy inhibitor

LYS05|LYS-05|lysosomal autophagy inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: Lys05|Cas Number: 1391426-22-4| Catalog Number: DC10508|Other Nmaes: Lys 05,Lys-05,Lys05

Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.

Lys05 is a new lysosomal autophagy inhibitor which potently accumulates within and deacidifies the lysosome of both cells and tumors, resulting in sustained inhibition of autophagy and tumor growth.