IRAK4-IN-1 |cas 1820787-94-7
DC Chemicals, Website: www.dcchemicals.com
Product Name: IRAK4-IN-1 |Cas Number: 1820787-94-7| Catalog Number: DC10584
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
The in vitro metabolic stability profiles of IRAK4-IN-1 (Compound 23) is measured, with EC50 of 2300 nM for the rat whole blood (RWB).
Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance (Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h.
没有评论:
发表评论