KKL-10|KKL10|cas 952849-76-2|ribosome rescue inhibitor

KKL-10|KKL10|cas 952849-76-2|ribosome rescue inhibitor

DC Chemicals, Website: www.dcchemicals.com

Product Name: KKL-10|Cas Number: 952849-76-2| Catalog Number: DC10567|Other Nmaes: KKL-10,KKL 10,KKL10

KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.

The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells.