AX-024|AX024|TCR inhibitor|cas 1704801-24-0
DC Chemicals, Website: www.dcchemicals.com
Product Name: AX-024|Cas Number: 1704801-24-0| Catalog Number: DC10545|Other Nmaes: AX-024,AX024,AX 024
AX-024 is the first-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM).
AX-024 is the first-in-class inhibitor of T cell receptor (TCR); AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). By modulating TCR signaling, the inhibitor prevented the development of psoriasis and asthma and, furthermore, exerted a long-lasting therapeutic effect in a model of autoimmune encephalomyelitis.
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