RO 5028442|cas 920022-47-5

RO 5028442|cas 920022-47-5

DC Chemicals, Website: www.dcchemicals.com

Product Name: RO 5028442|Cas Number: 920022-47-5| Catalog Number: DC10583|Other Nmaes: RO-5028442; RO 5028442; RO5028442

RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a).

Compounds 29, 31, and RO5028442 (compound 8) have excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. All compounds show high solubility. RO5028442 is found to be highly selective against a panel of 89 targets. Finally, RO5028442 is identified as a suitable compound for clinical studies.