PCO371|PCO-371|1613373-33-3|agonist of PTHR1

PCO371|PCO-371|1613373-33-3|agonist of PTHR1

DC Chemicals, Website: www.dcchemicals.com

Product Name: PCO371|Cas Number: 1613373-33-3| Catalog Number: DC10531|Other Nmaes: PCO 371,PCO371,PCO-371

PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1.

PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptors indicated that Proline 415 of PTHR1 is critical for PCO371-mediated PTHR1 activation. Oral administration of PCO371 to osteopenic rats provokes a significant increase in bone turnover with limited increase in bone mass. In hypocalcemic rats, PCO371 restores serum calcium levels without increasing urinary calcium, and with stronger and longer-lasting effects than PTH injections. These results strongly suggest that PCO371 can provide a new treatment option for PTH-related disorders, including hypoparathyroidism.