NVP-BEP800 |cas 847559-80-2 |DC Chemicals|Supplier|Price|Buy  

NVP-BEP800 |cas 847559-80-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: NVP-BEP800 ,cas 847559-80-2, Cat No. DC4118, In stock

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Product name: NVP-BEP800, Synonym:　VER-82576,NVP BEP800, Cat No. DC4118, Cas: 847559-80-2, Chemical Name:2-amino-4-(2,4-dichloro-5-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide, Molecular Formula: C21H23Cl2N5O2S, MW: 480.41

NVP-BEP800 Cas#847559-80-2.Purity:99%.Best Price and Quality in the Market!Supplied by DC Chemicals! NVP-BEP800 is a novel, fully synthetic HSP90β inhibitor with IC50 of 58 nM.

Description of NVP-BEP800: NVP-BEP800 is a novel, fully synthetic, orally bioavailable inhibitor that binds to the NH(2)-terminal ATP-binding pocket of Hsp90. NVP-BEP800 showed activity against a panel of human tumor cell lines and primary human xenografts in vitro at nanomolar concentrations. In A375 melanoma and BT-474 breast cancer cell lines, NVP-BEP800 induced client protein degradation (including ErbB2, B-Raf(V600E), Raf-1, and Akt) and Hsp70 induction. Oral administration of NVP-BEP800 was well tolerated and induced robust antitumor responses in tumor xenograft models, including regression in the BT-474 breast cancer model. In these tumor models, NVP-BEP800 modulated Hsp90 client proteins and downstream signaling pathways at doses causing antitumor activity. NVP-BEP800 showed in vivo activity in a variety of dosing regimens covering daily to weekly schedules, potentially providing a high degree of flexibility in dose and schedule within the clinical setting. Overall, given the mechanism of action, preclinical activity profile, tolerability, and pharmaceutical properties, NVP-BEP800 is an exciting new oral Hsp90 inhibitor warranting further development. (source: Mol Cancer Ther; 2010, 9(4); 906-19.)

For the detailed information about the solubility of NVP-BEP800 in water, the solubility of NVP-BEP800 in DMSO, the solubility of NVP-BEP800 in PBS buffer, the animal experiment of NVP-BEP800,the in vivo and in vitro test of NVP-BEP800,the cell experiment of NVP-BEP800,the IC50 and EC50 of NVP-BEP800please contact DC Chemicals.