Tubacin (BML-GR362) supplier|cas 537049-40-4 |DC Chemicals|Supplier|Price|Buy 

DC Chemials Supply: Tubacin (BML-GR362) supplier,cas 537049-40-4, Cat No. DC5178, In stock

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Product name: Tubacin (BML-GR362), Synonym:　N/A, Cat No. DC5178, Cas: 537049-40-4, Chemical Name:N1-(4-((2R,4R,6S)-4-(((4,5-diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide, Molecular Formula: C41H43N3O7S, MW: 721.86

Tubacin (BML-GR362),cas 537049-40-4, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2). Tubacin does not inhibit HDAC6 histone deacetylase activity. Instead, it reversibly inhibits α-tubulin deacetylation. Tubacin increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM. The IC50 for other HDACs is 1000-fold higher, making tubacin both more selective and more potent than Tubastatin A, which also inhibits HDAC8. Tubacin inhibits alpha-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin is a synthetic small molecule with chemical formula C41H43N3O7S and molecular weight: 721.86. It's chemical name is N1-(4-((2R,4R,6S)-4-(((4,5-diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide.