PF-562271 PHSO3H SALT |cas 939791-38-5 |DC Chemicals|Supplier|Price|Buy  

PF-562271 PHSO3H SALT |cas 939791-38-5 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply:PF-562271 PHSO3H SALT ,cas 939791-38-5, Cat No. DC3168, In stock

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Product name: PF-562271 PHSO3H SALT, Synonym:　PF 562271 PHSO3H SALT, Cat No. DC3168, Cas: 939791-38-5, Chemical Name:N-methyl-N-(3-((2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyrimidin-4-ylamino)methyl)pyridin-2-yl)methanesulfonamide benzenesulfonate, Molecular Formula: C21H20F3N7O3S.C6H6O3S, MW: 665.66

PF-562271 PHSO3H SALT Cas#939791-38-5.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

Description of PF-562271: PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. FAK inhibitor PF-00562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline-rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival. As FAK is a signal transducer for integrins, inhibition of FAK by this agent may prevent integrin-mediated activation of several downstream signals including ERK, JNK/MAPK and PI3K/Akt. FAK and PYK2, upregulated in many tumor cell types, are involved in tumor cell invasion, migration and proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

For the detailed information about the solubility of PF-562271 PHSO3H SALT in water, the solubility of PF-562271 PHSO3H SALT in DMSO, the solubility of PF-562271 PHSO3H SALT in PBS buffer, the animal experiment of PF-562271 PHSO3H SALT,the in vivo and in vitro test of PF-562271 PHSO3H SALT,the cell experiment of PF-562271 PHSO3H SALT,the IC50 and EC50 of PF-562271 PHSO3H SALTplease contact DC Chemicals.