WZ4002 supplier|cas 1213269-23-8 |DC Chemicals|Supplier|Price|Buy  

WZ4002 supplier|cas 1213269-23-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: WZ4002 supplier,cas 1213269-23-8, Cat No. DC5090, In stock

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Product name: WZ4002, Synonym:　WZ4002,WZ 4002,WZ-4002, Cat No. DC5090, Cas: 1213269-23-8, Chemical Name:N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide, Molecular Formula: C25H27ClN6O3, MW: 494.97

WZ4002,cas 1213269-23-8, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I).

WZ4002 is EGFR inhibitor against EGFR  T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. WZ4002 has a basic chemical framework (covalent pyrimidine) which is different from that of other EGFR inhibitors.  This agent is 30- to 100-fold more potent against EGFR T790M, and up to 100-fold less potent against wildtype EGFR, than quinazoline-based EGFR inhibitors (HKI-272 and CL-387,785) in vitro.