Veliparib (ABT-888) supplier|cas 912444-00-9 |DC Chemicals|Supplier|Price|Buy  

Veliparib (ABT-888) supplier|cas 912444-00-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: Veliparib (ABT-888) supplier,cas 912444-00-9, Cat No. DC5150, In stock

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Product name: Veliparib (ABT-888), Synonym:　ABT 888,ABT888, Cat No. DC5150, Cas: 912444-00-9, Chemical Name:N/A, Molecular Formula: C13H16N4O, MW: 244.29

Veliparib (ABT-888),cas 912444-00-9, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Veliparib is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.

Veliparib (ABT-888) is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.