CP-868596 (Crenolanib) supplier|cas 670220-88-9 |DC Chemicals|Supplier|Price|Buy  

CP-868596 (Crenolanib) supplier|cas 670220-88-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: CP-868596 (Crenolanib) supplier,cas 670220-88-9, Cat No. DC5159, In stock

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Product name: CP-868596 (Crenolanib), Synonym:　CP-868,596; CP-868596;  ARO 002;CP868596, Cat No. DC5159, Cas: 670220-88-9, Chemical Name:1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine., Molecular Formula: C26H29N5O2, MW: 443.54

CP-868596 (Crenolanib),cas 670220-88-9, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.

Crenolanib is an orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.