MLN2238 supplier|cas 1072833-77-2 |DC Chemicals|Supplier|Price|Buy  

MLN2238 supplier|cas 1072833-77-2 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: MLN2238 supplier,cas 1072833-77-2, Cat No. DC5086, In stock

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Product name: MLN2238, Synonym:　MLN-2238; MLN 2238; MLN2238., Cat No. DC5086, Cas: 1072833-77-2, Chemical Name:(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid, Molecular Formula: C14H19BCl2N2O4, MW: 361.03

MLN2238,cas 1072833-77-2, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM.

MLN-2238 is the biologically active form of MLN9708. MLN2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both MLN2238 and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only MLN2238 alleviated osteolytic bone disease in the DP54-Luc model. The antitumor activity of MLN2238 in a variety of mouse models of B-cell lymphoma and PCM, supporting its clinical development.