BKM120 (NVP-BKM120, Buparlisib) supplier|cas 944396-07-0 |DC Chemicals|Supplier|Price|Buy  

BKM120 (NVP-BKM120, Buparlisib) supplier|cas 944396-07-0 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: BKM120 (NVP-BKM120, Buparlisib) supplier,cas 944396-07-0, Cat No. DC5154, In stock

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Product name: BKM120 (NVP-BKM120, Buparlisib), Synonym:　NVP-BKM-120, BKM-120; Buparlisib, Cat No. DC5154, Cas: 944396-07-0, Chemical Name:5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine, Molecular Formula: C18H21F3N6O2, MW: 410.39

BKM120 (NVP-BKM120, Buparlisib),cas 944396-07-0, Purity: >98%. Best Price and quality in the market,DC Chemicals,Primary Manufacturer, confirmed by HNMR and HPLC. BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Phase 1/2.

Buparlisib, also known as BKM120,  is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3-kinase (PI3K) family of lipid kinases with potential antineoplastic activity. PI3K inhibitor BKM120 specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.