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Product name: WIN-55212-2 mesylate, Synonym: WIN552122,WIN-552122, Cat No. DC2050, Cas: 131543-23-2, Chemical Name:N/A, Molecular Formula: C28H30N2O6S, MW: 522.61
WIN-55212-2 mesylate Cas#131543-23-2.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! WIN 55212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.
(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.1 In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve.2 This effect at a concentration of 1 nM was fully counteracted by SR141716A (10 nM), by decreasing Ca2+ concentrations below 0.2 mM, and by the IP3 receptor antagonist xestospongin C at 1 ?M. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 of 26 ?M.3 In addition, (+)-WIN 55,212-2 (mesylate)-evoked CGRP release is not stereospecific, as the CB receptor-inactive enantiomer (+)-WIN 55,212-3 also stimulates CGRP exocytosis.For the detailed information about the solubility of WIN 55212-2 mesylate in water, the solubility of WIN 55212-2 mesylate in DMSO, the solubility of WIN 55212-2 mesylate in PBS buffer, the animal experiment of WIN 55212-2 mesylate,the in vivo and in vitro test of WIN 55212-2 mesylate,the cell experiment of WIN 55212-2 mesylate,the IC50 and EC50 of WIN 55212-2 mesylateplease contact DC Chemicals.
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