TAK-700 (Orteronel)|cas 566939-85-3 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: TAK-700 (Orteronel),cas 566939-85-3, Cat No. DC2009, In stock

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Product name: TAK-700 (Orteronel), Synonym:　TAK700, Orteronel, TAK 700, Cat No. DC2009, Cas: 566939-85-3, Chemical Name:(S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-e]imidazol-7-yl)-N-methyl-2-naphthamide, Molecular Formula: C18H17N3O2, MW: 307.35

TAK-700 (Orteronel)

 Cas#566939-85-3.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! TAK-700 (Orteronel) is a potent and highly selective rat and human 17,20-lyase inhibitor with IC50 of 54 nM and 38 nM, respectively.

Description of orteronel: Orterone (TAK-700) is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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