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Product name: GSK-1120212 (JTP-74057,trametinib), Synonym: GSK212, GSK 1120212 , JTP-74057, trametinib, GSK1120212, Cat No. DC1099, Cas: 871700-17-3, Chemical Name:N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide, Molecular Formula: C26H23FIN5O4, MW: 615.39
GSK-1120212 (JTP-74057,trametinib) Cas#871700-17-3.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.
Description of Trametinib: Trametinib is an orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
For the detailed information about the solubility of GSK1120212 (JTP-74057, trametinib) in water, the solubility of GSK1120212 (JTP-74057, trametinib) in DMSO, the solubility of GSK1120212 (JTP-74057, trametinib) in PBS buffer, the animal experiment of GSK1120212 (JTP-74057, trametinib),the in vivo and in vitro test of GSK1120212 (JTP-74057, trametinib),the cell experiment of GSK1120212 (JTP-74057, trametinib),the IC50 and EC50 of GSK1120212 (JTP-74057, trametinib)please contact DC Chemicals.
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