DC Chemicals supplies: EHT-1864,cas: 754240-09-0,Catalog: DC7627,In stock.
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Product name: EHT-1864, Synonyms: EHT-1864,EHT-1864, cas: 754240-09-0, MW: 581.47, Molecule Formula: C25H29Cl2F3N2O4S
EHT-1864, cas: 754240-09-0, From DC Chemicals. EHT 1864 is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
EHT 1864 selectively inhibits Rac-induced lamellipodia Formation, and specifically reverses cell trans Formation induced by constitutively activated mutants of Rac1 and Tiam1. EHT 1864 strongly impaires oncogenic Ras-induced cell proliferation in NIH 3T3 cells stably expressing H-Ras(61L) protein. [1] EHT 1864 also reduces both extracellular and intracellular levels of Aβ peptides by inhibiting the γ-secretase-dependent cleavage of APP. [2] In cultured hippocampal pyramidal neurons, EHT 1864, via inhibition of Rac1, rescues the phenotype induced by Rich2 knock-down. [3] EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains. [2]For the detailed information of EHT-1864, the solubility of EHT-1864 in water, the solubility of EHT-1864 in DMSO, the solubility of EHT-1864 in PBS buffer, the animal experiment (test) of EHT-1864, the cell expriment (test) of EHT-1864, the in vivo, in vitro and clinical trial test of EHT-1864, the EC50, IC50,and Affinity of EHT-1864, Please contact DC Chemicals.
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