SCR7 supplier|SCR-7|DC Chemicals

SCR7 supplier|SCR-7|DC Chemicals
DC Chemicals provides SCR7, other names: SCR7; SCR-7; SCR 7., cas: 1533426-72-0. In stock.

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SCR7 is a specific DNA Ligase IV inhibitor.

SCR7, other names: SCR7; SCR-7; SCR 7., cas: 1533426-72-0, Molecule formular: C18H14N4OS, Molecule Weight: 334.09, Chemical name: 5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

SCR7 is a specific DNA Ligase IV inhibitor. SCR7 inhibits end joining of double strand breaks in diverse cell types resulting in tumour regression by activation of p53 mediated apoptosis. Notably SCR7 treatment did not result in any adverse effects in mice and did not inhibit Ligase III.  The therapeutic efficacy of SCR7 could be enhanced by specific delivery of SCR7 to the tumour tissue and as adjuvant cancer therapy. SCR7 appears to be a potential cytotoxic anti-cancer drug candidate that can be used either alone or in combination with conventional DNA damaging drugs, owing to its specificity and absence of adverse effects in mice model. (source: J. Biosci. 39(3), June 2014, 339–340). (Last updated: 1/30/2015) For the detailed information of SCR7, the solubility of SCR7 in water, the solubility of SCR7 in DMSO, the solubility of SCR7 in PBS buffer, the animal experiment (test) of  SCR7, the cell expriment (test) of SCR7, the in vivo, in vitro and clinical trial test of SCR7, the EC50, IC50,and affinity,of SCR7, Please contact DC Chemicals.