DC Chemicals supplies: 4SC-202,cas: 910462-43-0,Catalog: DC7592,In stock.
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Product name: 4SC-202, Synonyms: 4SC-202, cas: 910462-43-0, MW: 447.51, Molecule Formula: C23H21N5O3S
4SC-202, cas 910462-43-0, Purity>98%. Best price and quality from DC Chemicals. Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1 CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor.2 It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.2
4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, the selective transcription of tumor suppressor genes, and the tumor suppressor protein-mediated inhibition of tumor cell division and eventually the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)For the detailed information of 4SC-202, the solubility of 4SC-202 in water, the solubility of 4SC-202 in DMSO, the solubility of 4SC-202 in PBS buffer, the animal experiment (test) of 4SC-202, the cell expriment (test) of 4SC-202, the in vivo, in vitro and clinical trial test of 4SC-202, the EC50, IC50,and Affinity of 4SC-202, Please contact DC Chemicals.
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