DC Chemicals supplies: LDN-57444,cas: 668467-91-2,Catalog: DC7610,In stock.
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Product name: LDN-57444, Synonyms: LDN-57444, cas: 668467-91-2, MW: 397.64, Molecule Formula: C17H11Cl3N2O3
LDN-57444, cas 668467-91-2, Purity>98%, In stock,from DC Chemicals. LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.Treatment with 50 μM LDN-57444 for 24 h leads to 70% inhibition of the proteasome activity. LDN-57444 causes a significant and concentration-dependent decrease in cell viability at concentrations above 25 μM and the cell viability reduced to 61.81% at 50 μM. LDN-57444 is able to cause cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate unfolded protein response. The apoptosis induced by LDN-57444 may be triggered by the activation of endoplasmic reticulum stress (ERS). [4] LDN-57444 causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Treatment with LDN also results in a rapid fall of Uch-L1 activity, but proteasome inhibition has no effect on cAMP levels over a period of several hours. [3]
Treatment with 50 μM LDN-57444 For 24 h leads to 70% inhibition of the proteasome activity. LDN-57444 causes a significant and concentration-dependent decrease in cell viability at concentrations above 25 μM and the cell viability reduced to 61.81% at 50 μM. LDN-57444 is able to cause cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate unfolded protein response. The apoptosis induced by LDN-57444 may be triggered by the activation of endoplasmic reticulum stress (ERS). [4] LDN-57444 causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Treatment with LDN also results in a rapid fall of Uch-L1 activity, but proteasome inhibition has no effect on cAMP levels over a period of several hours. [3]For the detailed information of LDN-57444, the solubility of LDN-57444 in water, the solubility of LDN-57444 in DMSO, the solubility of LDN-57444 in PBS buffer, the animal experiment (test) of LDN-57444, the cell expriment (test) of LDN-57444, the in vivo, in vitro and clinical trial test of LDN-57444, the EC50, IC50,and Affinity of LDN-57444, Please contact DC Chemicals.
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