LFM-A13 supplier|LFMA13|DC Chemicals
DC Chemicals provides LFM-A13, other names: LFMA13, cas: 244240-24-2. In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643267；
FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC₅₀’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK).
LFM-A13, other names: LFMA13, cas: 244240-24-2, Molecule formular: C11H8Br2N2O2, Molecule Weight: 360, Chemical name: 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide
Bruton’s tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating growth and differentiation of B-cells. BTK acts as an inhibitor of Fas/APO-1-mediated apoptosis in B-cells by preventing FAS-FADD interaction.1 LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties.2,1 It acts as an inhibitor of Bruton’s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (mouse recombinant) and 10 µM (Xenopus), respectively.2,3 LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and Cdk1, 2 and 3, as well as several other related kinases.2,3 LFM-A13 also exhibits anti-proliferative activity against Her2/Neu-overexpressing breast cancer cells. For the detailed information of LFM-A13, the solubility of LFM-A13 in water, the solubility of LFM-A13 in DMSO, the solubility of LFM-A13 in PBS buffer, the animal experiment (test) of LFM-A13, the cell expriment (test) of LFM-A13, the in vivo, in vitro and clinical trial test of LFM-A13, the EC50, IC50,and affinity,of LFM-A13, Please contact DC Chemicals.
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