DC Chemicals supplies: BIO,cas: 667463-62-9,Catalog: DC7663,In stock.
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Product name: BIO, Synonyms: GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, cas: 667463-62-9, MW: 356.17, Molecule Formula: C16H10BrN3O2
BIO, cas: 667463-62-9, From DC Chemicals. BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAKinhibitor.
BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of glycogen synthase kinase-3 (GSK-3), with IC50 of 5 nM For GSK-3α/β, shows >16-fold selectivity over CDK5. BIO interacts within the ATP binding pocket of these kinases, reduces β-catenin phosphorylation on a GSK-3-specific site in cellular models, closely mimicks Wnt signaling in Xenopus embryos. In human and mouse embryonic stem cells, BIO maintains the undifferentiated phenotype and sustains expression of the pluripotent state-specific transcription factors Oct-3/4, Rex-1 and Nanog. BIO-mediated Wnt activation is functionally reversible, as withdrawal of the compound leads to normal multidifferentiation programs in both human and mouse embryonic stem cells. BIO promotes proliferation in mammalian cardiomyocytes. 6BIO is also a pan-JAK inhibitor, with IC50 values of 0.03, 1.5, 8.0, 0.5 μM For TYK2, JAK1, JAK2 and JAK3. BIO selectively inhibits phosphorylation of STAT3 and induces apoptosis of human melanoma cells.BIO suppresses melanoma tumor growth in a mouse xenograft model.For the detailed information of BIO, the solubility of BIO in water, the solubility of BIO in DMSO, the solubility of BIO in PBS buffer, the animal experiment (test) of BIO, the cell expriment (test) of BIO, the in vivo, in vitro and clinical trial test of BIO, the EC50, IC50,and Affinity of BIO, Please contact DC Chemicals.
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