GNE-493 supplier|GNE493|DC Chemicals
DC Chemicals provides GNE-493, other names: GNE 493，GNE493, cas: 1033735-94-2. In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643283；
GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively.
GNE-493, other names: GNE 493，GNE493, cas: 1033735-94-2, Molecule formular: C17H20N6O2S, Molecule Weight: 372.44, Chemical name: 2-(2-(2-aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol
GNE-493 has good pharmacokinetic (PK) parameters, GNE-493 is highly selective, demonstrate knock down of pathway markers in vivo, and are efficacious in xenograft models where the PI3K pathway is deregulated. GNE-493 was compared in a PI3KR mutated MCF7.1 xenograft model and were found to have equivalent efficacy when normalized for exposure. For the detailed information of GNE-493, the solubility of GNE-493 in water, the solubility of GNE-493 in DMSO, the solubility of GNE-493 in PBS buffer, the animal experiment (test) of GNE-493, the cell expriment (test) of GNE-493, the in vivo, in vitro and clinical trial test of GNE-493, the EC50, IC50,and affinity,of GNE-493, Please contact DC Chemicals.
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